Amphoteric compostion and polymeric forms of alpha hydroxyacids, and their therapeutic use

• US 5,886,042 A
• Filed: 12/29/1997
• Issued: 03/23/1999
• Est. Priority Date: 08/15/1989
• Status: Expired due to Fees

• Current Assignee: Tristrata Technology Incorporated (Johnson & Johnson)
• Original Assignee: Tristrata Technology Incorporated (Johnson & Johnson)
• Inventors: Yu, Ruey J., Van Scott, Eugene J.
• Primary Examiner(s): Dees, Jose' G.
• Assistant Examiner(s): WILLIAMSON, MICHAEL A
• Application Number:
  US08/998,871
• Time in Patent Office: 449 Days
• Field of Search: 514/2, 514/12, 514/19, 514/23, 514/114, 514/349, 514/399, 514/419, 514/518, 514/561, 514/562, 514/567, 514/532, 514/547, 514/558, 514/844, 514/941, 424/59, 424/401, 424/557, 549/274, 528/354, 528/357, 528/361, 525/408, 525/411, 525/413, 525/415
• US Class Current: 514/557
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/191 having two or more hydroxy groups, e.g. gluconic acid
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/20 having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61K 31/366 having six-membered rings, e.g. delta-lactones
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61K 31/405 Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/66 Phosphorus compounds
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 31/765 Polymers containing oxygen
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/12 : Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/14 : Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/183 : Amino acids, e.g. glycine, EDTA or aspartame
• CPC Class Codes: A61K 47/20 : containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• CPC Class Codes: A61K 47/24 : containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 47/26 : Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 8/26 : Aluminium; Compounds thereof
• CPC Class Codes: A61K 8/27 : Zinc; Compounds thereof
• CPC Class Codes: A61K 8/347 : Phenols
• CPC Class Codes: A61K 8/362 : Polycarboxylic acids
• CPC Class Codes: A61K 8/365 : Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/37 : Esters of carboxylic acids
• CPC Class Codes: A61K 8/375 : the alcohol moiety containing more than one hydroxy group
• CPC Class Codes: A61K 8/41 : Amines
• CPC Class Codes: A61K 8/416 : Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/42 : Amides
• CPC Class Codes: A61K 8/43 : Guanidines
• CPC Class Codes: A61K 8/44 : Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/4913 : having five membered rings, e.g. pyrrolidone carboxylic acid
• CPC Class Codes: A61K 8/494 : with more than one nitrogen as the only hetero atom
• CPC Class Codes: A61K 8/4953 : containing pyrimidine ring derivatives, e.g. minoxidil
• CPC Class Codes: A61K 8/4973 : with oxygen as the only hetero atom
• CPC Class Codes: A61K 8/55 : Phosphorus compounds
• CPC Class Codes: A61K 8/553 : Phospholipids, e.g. lecithin
• CPC Class Codes: A61K 8/585 : Organosilicon compounds
• CPC Class Codes: A61K 8/60 : Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/63 : Steroids; Derivatives thereof
• CPC Class Codes: A61K 8/64 : Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/671 : Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/675 : Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde tocopheryl nicotinate A61K8/678
• CPC Class Codes: A61K 8/678 : Tocopherol, i.e. vitamin E
• CPC Class Codes: A61K 8/68 : Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
• CPC Class Codes: A61K 8/8152 : Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/85 : Polyesters
• CPC Class Codes: A61K 9/0014 : Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61Q 15/00 : Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/00 : Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: A61Q 17/04 : Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 : Preparations for dry skin
• CPC Class Codes: A61Q 19/008 : Preparations for oily skin
• CPC Class Codes: A61Q 19/02 : for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations
• CPC Class Codes: A61Q 19/10 : Washing or bathing preparations
• CPC Class Codes: A61Q 5/00 : Preparations for care of the hair
• CPC Class Codes: A61Q 5/006 : Antidandruff preparations
• CPC Class Codes: A61Q 5/02 : Preparations for cleaning the hair
• CPC Class Codes: A61Q 7/00 : Preparations for affecting hair growth
• CPC Class Codes: B24D 11/02 : Backings, e.g. foils, webs, mesh fabrics
• CPC Class Codes: B24D 18/00 : Manufacture of grinding tools or other grinding devices, e.g. wheels, not otherwise provided for

Abstract

Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.

Claims

1. A composition comprising:

A. an amphoteric or pseudoamphoteric agent

wherein said amphoteric or pseudoamphoteric agent comprises at least one member selected from the group consisting of amino acid, dipeptide, creatine, aminoaldonic acid, aminouronic acid, lauryl aminopropylglycine, aminoaldaric acid, neuraminic acid, desulfated heparin, deacetylated hyaluronic acid, hyalobiuronic acid, chondrosine, deacetylated chondroitin, creatinine, cocoamphoglycine, cocoamphopropionate, hydroxyproline, proline, homocysteine, homocystine, homoserine, ornithine, citrulline, phosphatidylserine, and sphingomyelin; and

B. a compound related to an alpha hydroxyacid or alpha ketoacid selected from the group consisting of ascorbic acid, quinic acid, isocitric acid, tropic acid, trethocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricic acid, 2-hydroxynervonic acid, aleuritic acid and pantoic acid.

2. The composition as claimed in claim 1, wherein the related compound is ascorbic acid.

3. The composition as claimed in claim 1, wherein the related compound is quinic acid.

4. The composition as claimed in claim 1, wherein the related compound is isocitric acid.

5. The composition as claimed in claim 1, wherein the related compound is tropic acid.

6. The composition as claimed in claim 1, wherein the related compound is trethocanic acid.

7. The composition as claimed in claim 1, wherein the related compound is 3-chlorolactic acid.

8. The composition as claimed in claim 1, wherein the related compound is cerebronic acid.

9. The composition as claimed in claim 1, wherein the related compound is citramalic acid.

10. The composition as claimed in claim 1, wherein the related compound is agaricic acid.

11. The composition as claimed in claim 1, wherein the related compound is 2-hydroxynervonic acid.

12. The composition as claimed in claim 1, wherein the related compound is aleuritic acid.

13. The composition as claimed in claim 1, wherein the related compound is pantoic acid.

14. The composition as claimed in claim 1, further comprising a cosmetic agent or a pharmaceutical agent for topical treatment of dermatological disorders.

15. The composition as claimed in claim 14, wherein the cosmetic agent or pharmaceutical agent is selected from the group consisting of cosmetic or pharmaceutical agent is selected from the group consisting of clotrimazole, ketoconazole, miconazole, griseofulvin, hydroxyzine, diphenhydramine, pramoxine, lidocaine, procaine, mepivacaine, hydroquinone, monobenzone, erythromycin, tetracycline, clindamycin, meclocycline, minocycline, naproxen, ibuprofen, theophylline, cromolyn, albuterol, retinoic acid, 13-cis retinoic acid, hydrocortisone, hydrocortisone 21-acetate, hydrocortisone 17-valerate, hydrocortisone 17-butyrate, betamethasone dipropionate, triamcinolone acetonide, fluocinonide, clobetasol propionate, benzoyl peroxide, crotamiton, propranolol, promethazine, vitamin A acetate, vitamin A palmitate and vitamin E acetate.