Radiolabeled thrombus imaging agents
First Claim
Patent Images
1. A composition having formula I or II:
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space="preserve" listing-type="equation">M-Z-X.sub.1 -P-X.sub.2 (I)
space="preserve" listing-type="equation">X.sub.1 -P-X.sub.2 -Z-M (II)wherein;
M is a radiolabeling moiety comprised of four amino acids capable of complexing with a selected radionuclide in an N4 configuration;
Z is a linker comprising one or more natural or synthetic amino acids;
X1 is from zero to twenty natural or synthetic amino acids;
p is a peptide comprising a sequence Cys Ser Val Thr Cys Gly (SEQ ID NO;
4), or an analog or fragment thereof; and
X2 is from zero to twenty natural or synthetic amino acids.
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Abstract
This invention relates to a radiodiagnostic agent to image arterial and venous thrombi, pulmonary emboli and lesions of atherosclerosis. A composition for a thrombus imaging agent, a method and kit for preparing a thrombus imaging agent, and a radiolabeling reagent for preparing the thrombus imaging agent are provided. Methods of using the thrombus imaging agent to detect thrombi are also provided.
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Citations
5 Claims
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1. A composition having formula I or II:
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space="preserve" listing-type="equation">M-Z-X.sub.1 -P-X.sub.2 (I)
space="preserve" listing-type="equation">X.sub.1 -P-X.sub.2 -Z-M (II)wherein; M is a radiolabeling moiety comprised of four amino acids capable of complexing with a selected radionuclide in an N4 configuration; Z is a linker comprising one or more natural or synthetic amino acids; X1 is from zero to twenty natural or synthetic amino acids; p is a peptide comprising a sequence Cys Ser Val Thr Cys Gly (SEQ ID NO;
4), or an analog or fragment thereof; andX2 is from zero to twenty natural or synthetic amino acids. - View Dependent Claims (2, 3, 4, 5)
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Specification
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Current AssigneeThomas Jefferson University (Main Line Health System)
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Original AssigneeThomas Jefferson University (Main Line Health System)
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InventorsThakur, Mathew L., Pallela, Venkataramana R.
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Primary Examiner(s)DAVENPORT, AVIS MICHELLE
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Application NumberUS08/858,971Time in Patent Office672 DaysField of Search424/1.11, 424/1.69, 424/1.65, 514/15, 514/14, 514/13, 514/12, 530/300, 530/327, 530/326, 530/325, 530/324, 530/304US Class Current530/304CPC Class CodesA61K 2123/00 Preparations for testing in...A61K 51/088 conjugates with carriers be...C07K 14/78 Connective tissue peptides,...
