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Nucleotide analogs

  • US 5,886,179 A
  • Filed: 12/29/1995
  • Issued: 03/23/1999
  • Est. Priority Date: 09/17/1993
  • Status: Expired due to Term
First Claim
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1. A compound having the structure of formula (1) ##STR36## wherein B is 5-fluorocytosin-1-yl, 5-methylcytosin-1-yl, or a heterocyclic base having the structure (a) ##STR37## R is --S(O)2 N(R3)2 ;

  • each R1 is independently hydrogen, cyano, nitro, alkyl, O-alkyl, --C(O)R3, --S(O)2 OH, --N(R3)2 or --CHO;

    each R3 is independently hydrogen, alkyl, phenyl, phenyl substituted with C1-20 alkyl, --CH2 C6 H5 or --CH2 CH2 C6 H5, but when R1 is --N(R3)2, one R3 is hydrogen and the other R3 is C2-6 alkyl or when R1 is --N(R3)2, both R3 are the same and are C2-6 alkyl;

    R6 is --NH2, --NHR7, --NHR8, --N═

    CHN(R7)2 or --N═

    C(CH3)N(R7)2 ;

    R7 is C1 -C6 alkyl;

    R8 is a protecting group; and

    each R9 independently is N or CH.

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