Multilayer integrated assembly for effecting fluid handling functions

• US 5,888,390 A
• Filed: 04/30/1997
• Issued: 03/30/1999
• Est. Priority Date: 04/30/1997
• Status: Expired due to Term

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Hewlett-Packard Company (HP Inc.)
• Inventors: Craig, Stephen R.
• Primary Examiner(s): Therkorn, Ernest G.
• Application Number:
  US08/845,974
• Time in Patent Office: 699 Days
• Field of Search: 210/635, 210/656, 210/659, 210/198.2, 204/601, 204/602, 204/603, 204/604, 204/605, 204/451, 204/452, 204/453, 204/454, 422/68.1, 422/69, 422/70
• US Class Current: 210/198.2
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2300/043 Hinged closures
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/1827 using resistive heater
• CPC Class Codes: B01L 2400/0421 electrophoretic flow
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/505 flexible containers not provided for above
• CPC Class Codes: G01N 30/6095 Micromachined or nanomachined, e.g. micro- or nanosize

Abstract

A multilayer integrated assembly for effecting fluid handling functions includes complementary microstructures formed by an etching or similar process in a planar foldable substrate. The complementary microstructures may be superimposed in a controlled manner by operation of micro-alignment means also formed in the foldable substrate by an etching or similar process. Microstructures are contemplated as including channels (that may be superimposed to form fluid conduits), apertures, conduit apertures, sample processing compartments, and the like. The resulting integrated assembly may be bonded and subsequently operated to implement one or more fluid-handling functions.

Claims

1. A multilayer integrated assembly for effecting fluid handling functions, comprising:

a planar foldable substrate having a linear fold means, the linear fold means defining a linear fold axis and at least first and second component sections, wherein said substrate is comprised of a material that is ductile in the region of the linear fold means and substantially inextensible in the regions defined by the component sections, wherein said first and second component sections include respective first and second surface features on respective first and second mating surfaces, wherein the surface features are aligned and superimposed upon folded closure of the planar foldable substrate at the linear fold axis to form a fluid handling functional device in a unitary planar assembly.

2. The integrated assembly of claim 1, further comprising n component sections and (n-1) linear fold means, wherein n equals three or more, and wherein the component sections are closed upon one another in a Z-fold configuration.

3. The integrated assembly of claim 1, wherein the first and second mating surfaces are susceptible to diffusion bonding at a desired diffusion bonding temperature.

4. The integrated assembly of claim 3, wherein at least one of the surface features further includes a surface defect and further comprising a surface layer in at least one of the first and second mating surfaces formulated to melt a the desired diffusion bonding temperature, thus forming an amount of transient liquid phase, whereby the amount of the transient liquid phase fills the surface defect.

5. The integrated assembly of claim 4, wherein the surface defect is located at the interface of the first and second surface features.

6. The integrated assembly of claim 5, wherein the first and second surface features further comprise first and second complementary microstructures.

7. The integrated assembly of claim 5, wherein the first and second surface features further comprise complementary microstructures and wherein the transient liquid phase flows into a surface defect located at the interface of the first and second complementary microstructures.

8. The integrated assembly of claim 3, wherein the foldable substrate further comprises a substrate material selected from the group consisting of:

metals, metal alloys, steels, and stainless steel.

9. The integrated assembly of claim 1, wherein the linear fold means includes a fold relief for relieving stress or deformation induced in the substrate in the immediate area of the fold axis during operation of the linear fold means.

10. The integrated assembly of claim 1, further comprising corroboration means for corroborating the alignment of the first and second surface features.

11. The integrated assembly of claim 1, wherein the planar foldable substrate further comprises a surface feature selected from the group consisting of:

a microstructure, conductor, semiconductor, insulator, electrode, sensor, sensor array, catalyst, orifice, screen, well, restriction, frit, perforation, porous section, permeable region, and semi-permeable region.

12. The integrated assembly of claim 1, wherein the surface treatment is selected from the group consisting of:

a chemically-active region, a biologically-active region, and a region having at least one optical, electrical, opto-electrical, magneto-optical, or magnetic characteristic.

13. The integrated assembly of claim 1, wherein an intermediary substrate is interposed between at least two of the component sections.

14. The integrated assembly of claim 13, wherein the intermediary substrate further comprises a surface feature selected from the group consisting of:

a microstructure, conductor, semiconductor, insulator, electrode, sensor, sensor array, catalyst, orifice, screen, well, restriction, frit, perforation, porous section, permeable region, and semi-permeable region.

15. The integrated assembly of claim 13, wherein the intermediary substrate includes a surface treatment selected from the group consisting of:

a chemically-active region, a biologically-active region, and a region having at least one optical, electrical, opto-electrical, magneto-optical, or magnetic characteristic.

16. The integrated assembly of claim 13, wherein at least one of the intermediary substrate and the planar foldable substrate further comprises corroboration means for corroborating the alignment of the intermediary substrate and the planar foldable substrate.

17. The integrated assembly of claim 13, wherein the intermediary substrate and the first and second mating surfaces are susceptible to diffusion bonding at a desired diffusion bonding temperature.

18. The integrated assembly of claim 1, wherein the intermediary substrate further comprises a substrate material that differs from the planar foldable substrate.

19. A multilayer integrated assembly for effecting fluid handling functions for use in a sample analysis system, comprising:

a planar foldable substrate having a linear fold means, the linear fold means defining a linear fold axis and first and second component sections, wherein said substrate is comprised of a material that is ductile in the region of the linear fold means and substantially inextensible in the regions defined by the component sections, wherein said first and second component sections include respective first and second channels on respective first and second mating surfaces, wherein the first and second channels are aligned and superimposed by folding the substrate at the linear fold axis and said first and second mating surfaces are subject to diffusion bonding at a desired diffusion bonding temperature, whereby said aligned and superimposed first and second channels form a conduit having inlet and outlet ends, and wherein said planar foldable substrate in folded form provides a unitary planar assembly, and inlet and outlet apertures respectively communicating with the inlet and outlet ends of the conduit for effecting fluid flow of a sample therein, whereby the integrated assembly is useable for effecting fluid flow in the conduit.

20. The integrated assembly of claim 19, wherein an intermediary substrate is interposed between the first and second component sections.

21. The integrated assembly of claim 20, wherein the intermediary substrate further comprises a surface feature selected from the group consisting of:

a microstructure, conductor, semiconductor, insulator, electrode, sensor, sensor array, catalyst, orifice, screen, well, restriction, frit, perforation, porous section, permeable region, and semi-permeable region.

22. The integrated assembly of claim 20, wherein the intermediary substrate includes a surface treatment selected from the group consisting of:

a chemically-active region, a biologically-active region, and a region having at least one optical, electrical, opto-electrical, magneto-optical, or magnetic characteristic.

23. The integrated assembly of claim 20, wherein at least one of the intermediary substrate and the planar foldable substrate further comprises corroboration means for corroborating the alignment of the intermediary substrate with at least one of the first and second component sections.

24. The integrated assembly of claim 19, wherein the first and second mating surfaces are susceptible to diffusion bonding at a desired diffusion bonding temperature.

25. The integrated assembly of claim 24, further comprising:

a surface feature on at least one of said first and second mating surfaces, wherein the surface feature further includes a surface defect;

each of said first mating surface and second mating surface having a respective surface layer, said respective surface layers being formulated to melt at the desired diffusion bonding temperature, thus forming an amount of transient liquid phase during diffusion bonding, whereby the formation of the amount of the transient liquid phase alters the surface defect.