Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
First Claim
1. A method of enhancing the rate at which an inhaled drug migrates into a patient'"'"'s circulatory system, comprising:
- aerosolizing a formulation comprised of a monomeric insulin;
inhaling the aerosolized formulation into lungs of a patient and allowing particles of the monomeric insulin to deposit on lung tissue.
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Accused Products
Abstract
The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient'"'"'s lungs and the rate at which the insulin is absorbed into the blood is increased by the use of monomeric insulin and/or an inhale-exhale breathing maneuver. Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The rate of absorption is enhanced by the monomeric form of insulin and by instructing the patient to inhale maximally and thereafter exhale maximally. This maneuver causes a spike in the rate at which insulin enters the circulatory system thereby increasing the rate at which glucose is removed from the circulatory system. The insulin or insulin analog may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release. The sensor can also assist the patient in the inhale-exhale maneuver.
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Citations
21 Claims
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1. A method of enhancing the rate at which an inhaled drug migrates into a patient'"'"'s circulatory system, comprising:
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aerosolizing a formulation comprised of a monomeric insulin; inhaling the aerosolized formulation into lungs of a patient and allowing particles of the monomeric insulin to deposit on lung tissue. - View Dependent Claims (2, 3, 4, 12, 13, 14)
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5. A method of improving the bioavailability of insulin delivered via the lung, comprising:
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aerosolizing a formulation of an insulin analog which analog rapidly disassociates into monomeric form; inhaling the aerosolized formulation of the insulin analog into the lungs in a manner which allows the particles of the insulin analog to deposit on the lung tissue. - View Dependent Claims (6)
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7. A method of reducing sequestration of drug on lung tissue, comprising:
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aerosolizing a formulation comprised of a monomeric insulin; inhaling the aerosolized formulation into lungs of a patient and allowing particles of the monomeric insulin to deposit on lung tissue. - View Dependent Claims (8, 9, 10, 11)
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15. A method of reproducibly effecting a serum glucose level, comprising:
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aerosolizing a formulation comprising monomeric insulin; administering the aerosolized formulation. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification