Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component

• US 5,888,510 A
• Filed: 04/07/1997
• Issued: 03/30/1999
• Est. Priority Date: 07/21/1993
• Status: Expired due to Term

• Current Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG), Tadamitsu Kishimoto
• Original Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG), Tadamitsu Kishimoto
• Inventors: Mihara, Masahiko, Kishimoto, Tadamitsu, Ohsugi, Yoshiyuki, Moriya, Yoichiro
• Primary Examiner(s): Saunders, David
• Assistant Examiner(s): VANDERVEGT, FRANCOIS P
• Application Number:
  US08/817,084
• Time in Patent Office: 722 Days
• Field of Search: 424/145.1, 424/141.1, 424/810, 530/388.23, 530/389.2, 514/2
• US Class Current: 424/141.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: C07K 16/248 IL-6
• CPC Class Codes: C07K 16/2866 against receptors for cytokines, lymphokines, interferons
• CPC Class Codes: C07K 2317/73 Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
• CPC Class Codes: Y10S 424/81 involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy

Abstract

Methods for inhibiting synovial cell growth and treating chronic rheumatoid arthritis are provided. The methods comprise administering a pharmaceutical composition comprising an interleukin-6 antagonist, such as an anti-IL-6 receptor antibody, and a physiologically acceptable carrier.

Claims

1. A method for inhibiting synovial cell growth, comprising administering to a patient in need thereof a pharmaceutical composition comprising an interleukin-6 antagonist and a physiologically acceptable carrier.

2. The method according to claim 1, wherein the interleukin-6 antagonist is selected from the group consisting of an interleukin-6 antibody and an interleukin-6 receptor antibody.

3. The method according to claim 2, wherein the antagonist is a monoclonal antibody.

4. The method according to claim 1, wherein the patient is a human.

5. The method according to claim 4, wherein the antagonist is administered in four divided doses of from about to 1000 mg.

6. A method of treating chronic rheumatoid arthritis, comprising administering to a patient in need thereof a pharmaceutical composition comprising an antibody against an interleukin-6 receptor and a physiologically acceptable carrier.

7. The method according to claim 6, wherein the antibody suppresses abnormal growth of synovial cells.

8. The method according to claim 6, wherein the antibody is an antibody against a human interleukin-6 receptor.

9. The method according to claim 6, wherein the antibody is a monoclonal antibody.

10. The method according to claim 6, wherein the patient is a human.

11. The method according to claim 10, wherein the antibody is administered in four divided doses of from about 1 to 1000 mg.