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Selective enzymatic oxidation of aromatic methyl groups to aldehydes by oxygen in the presence of a laccase-mediator catalyst

  • US 5,888,787 A
  • Filed: 07/02/1996
  • Issued: 03/30/1999
  • Est. Priority Date: 07/02/1996
  • Status: Expired due to Fees
First Claim
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1. A method for manufacturing a corresponding aromatic aldehyde compound from an aromatic compound, the method comprising:

  • (A) providing (i) an aromatic compound, having a pendent methyl moiety substituted on at least one carbon of the aromatic compound with at least one unsubstituted position ortho to the carbon substituted with the pendent methyl moiety, for catalytic conversion into the corresponding aromatic aldehyde compound, (ii) a mediator, and (iii) a laccase, wherein the aromatic compound and the mediator are present in a mmol ratio of the aromatic compound to the mediator of about 1000;

    5 to about 1000;

    11, and a sufficient amount of the laccase is present to provide about 25 to about 210 Units of enzymatic activity;

    (B) reacting the aromatic compound, the mediator, and the laccase of step (A) in the presence of oxygen at a temperature from about 20°

    C. to about 40°

    C. and a pressure from about 740 mm to about 780 mm and a pH from about 4.0 to about 6.0; and

    (C) obtaining the corresponding aromatic aldehyde.

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