Use of cotinine in treating psychiatric disorders

• US 5,889,029 A
• Filed: 11/13/1997
• Issued: 03/30/1999
• Est. Priority Date: 07/30/1996
• Status: Expired due to Fees

• Current Assignee: LecTec Corporation
• Original Assignee: LecTec Corporation
• Inventors: Rolf, David
• Primary Examiner(s): Spivack, Phyllis G.
• Application Number:
  US08/969,767
• Time in Patent Office: 502 Days
• Field of Search: 514/343
• US Class Current: 514/343
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/465 Nicotine; Derivatives thereof

Abstract

Methods are provided for treating schizophrenia, Tourette'"'"'s Syndrome, obsessive-compulsive disorder, substance abuse or substance addiction including drug or alcohol addiction, manic-depression syndrome, anexoria or bulimia comprising administering an amount of cotinine or a pharmaceutically acceptable salt thereof, which amount is effective to reduce or alleviate at least one of the symptoms of schizophrenia, Tourette'"'"'s Syndrome, obsessive-compulsive disorder, substance abuse or substance addiction including drug or alcohol addiction, manic-depression syndrome, anexoria or bulimia in a human or other mammal.

Claims

1. A method of treating a patient suffering from obsessive-compulsive disorder, said method comprising,

providing for such a patient a pharmaceutical agent comprising cotinine or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 mg/kg to 100 mg/kg body weight per day for alleviating, in a human in need of such treatment, at least one of the symptoms of obsessive-compulsive disorder.

2. The method of claim 1 wherein the pharmaceutical agent or said salt is selected from the group consisting of a tablet or capsule, a transdermal delivery system, a chewing gum, an interocular insert, an inhaler and an aqueous solution of cotinine.

3. A method of treating a patient suffering from Tourette'"'"'s Syndrome, said method comprising,

providing for such a patient a pharmaceutical agent comprising cotinine or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 mg/kg to 100 mg/kg body weight per day for alleviating, in a human in need of such treatment, at least one of the symptoms of Tourette'"'"'s Syndrome.

4. The method of claim 3 wherein said pharmaceutical agent or said salt is selected from the group consisting of a tablet or capsule, a transdermal delivery system, a chewing gum, an interocular insert, an inhaler and an aqueous solution of cotinine.

5. A method of treating a patient suffering schizophrenia, said method comprising,

providing for such a patient a pharmaceutical agent comprising cotinine or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 mg/kg to 100 mg/kg body weight per day for alleviating, in a human in need of such treatment, at least one of the symptoms of schizophrenia.

6. The method of claim 5 wherein the pharmaceutical agent or said salt is selected from the group consisting of a tablet or capsule, a transdermal delivery system, a chewing gum, an interocular insert, an inhaler and an aqueous solution of cotinine.

7. A method of treating a patient suffering from substance abuse or substance addiction, said method comprising,

providing for such a patient a pharmaceutical agent comprising cotinine or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 mg/kg to 100 mg/kg body weight per day for alleviating, in a human in need of such treatment, at least one of the symptoms of substance abuse or substance addiction.

8. The method of claim 7 wherein the pharmaceutical agent or said salt is selected from the group consisting of a tablet or capsule, a transdermal delivery system, a chewing gum, an interocular insert, an inhaler and an aqueous solution of cotinine.

9. The method of claim 7 wherein the addiction comprises drug or alcohol addiction.

10. The method of claim 9 wherein the pharmaceutical agent or said salt is selected from the group consisting of a tablet or capsule, a transdermal delivery system, a chewing gum, an interocular insert, an inhaler and an aqueous solution of cotinine.

11. A method of treating a patient suffering from manic-depression syndrome, said method comprising,

providing for such a patient a pharmaceutical agent comprising cotinine or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 mg/kg to 100 mg/kg body weight per day for alleviating, in a human in need of such treatment, at least one of the symptoms of manic-depression syndrome.

12. The method of claim 11 wherein the pharmaceutical agent or said salt is selected from the group consisting of a tablet or capsule, a transdermal delivery system, a chewing gum, an interocular insert, an inhaler and an aqueous solution of cotinine.

13. A method of treating a patient suffering from anorexia or bulimia, said method comprising,

providing for such a patient a pharmaceutical agent comprising cotinine or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 mg/kg to 100 mg/kg body weight per day for alleviating, in a human in need of such treatment, at least one of the symptoms of anorexia or bulimia.

14. The method of claim 13 wherein the pharmaceutical agent or said salt is selected from the group consisting of a tablet or capsule, a transdermal delivery system, a chewing gum, an interocular insert, an inhaler and an aqueous solution of cotinine.