Photolabile nucleoside protecting groups
First Claim
Patent Images
1. A compound having the following formula:
- ##STR25## wherein Y is a nucleic acid;
R1 and R2 are selected independently from hydrogen, lower alkyl and alkoxy; and
R3 is lower alkyl.
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Abstract
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
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25 Claims
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1. A compound having the following formula:
- ##STR25## wherein Y is a nucleic acid;
R1 and R2 are selected independently from hydrogen, lower alkyl and alkoxy; andR3 is lower alkyl. - View Dependent Claims (2, 3, 4)
- ##STR25## wherein Y is a nucleic acid;
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5. A compound having the following formula:
- ##STR26## wherein B is selected from the group consisting of adenyl, guanyl, cytidyl, thymidyl and uridyl;
X is hydrogen, a solid support, an oligonucleotide or an activated phosphorous group selected from the group consisting of phosphotriester and phosphoramidite; and R1 and R2 are selected independently from hydrogen, lower alkyl and alkoxy; and
R3 is lower alkyl. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- ##STR26## wherein B is selected from the group consisting of adenyl, guanyl, cytidyl, thymidyl and uridyl;
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22. A compound having the following formula:
- ##STR27## wherein Y is an oxygen group of a linker molecule;
R1 and R2 are selected independently from hydrogen, lower alkyl and alkoxy; andR3 is lower alkyl. - View Dependent Claims (23, 24, 25)
- ##STR27## wherein Y is an oxygen group of a linker molecule;
Specification