Multiple chamber catheter delivery system

• US 5,891,084 A
• Filed: 01/27/1997
• Issued: 04/06/1999
• Est. Priority Date: 12/27/1994
• Status: Expired due to Fees

• Current Assignee: Vincent W. Lee
• Original Assignee: Vincent W. Lee
• Inventors: Lee, Vincent W.
• Primary Examiner(s): MCDERMOTT, CORRINE MARIE
• Application Number:
  US08/789,501
• Time in Patent Office: 799 Days
• Field of Search: 604/49, 604/54, 604/96, 604/164, 604/171, 604/173, 604/174, 604/264, 604/280, 604/289, 604/290, 604/294
• US Class Current: 604/521
• CPC Class Codes: A61F 9/00736 Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments A61F9/008 takes precedence
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence

Abstract

A catheter system comprising of a catheter sheath and a multichamber balloon catheter capable of simultaneous or sequential delivery of substances such as drugs, anesthetics, biologicals or wound modulating agents into an organ or tissue remote from the point of entry of the catheter system. A specific use of such catheter system is for the timed application of wound modulating agents prior to the formation of a fistula in the filtration procedure used for the management of glaucoma. Another use is for the application and subsequent washing of the scar formation with wound modulating agents after an unsuccessful glaucoma filtration procedure. Substances requiring controlled release is applied through one lumen of the balloon catheter whose exit port is covered with a semipermeable or microporous membrane. Other substances not requiring controlled or slow release is applied through a second lumen where the substance can exit freely through a hole at one end of the second lumen. Retrieval of applied substances is also possible through gentle suction from the second lumen or a third lumen if needed.

Claims

1. A method for correcting glaucoma comprising:

(a) introducing a catheter sheath having a holding means to a desired location of the eye;

(b) inserting a balloon catheter having a first and second chamber into the catheter sheath;

(c) delivering a wound modulating agent through the second chamber of the balloon catheter to the desired location of the eye;

(d) washing the applied wound modulating agent with a washing solution introduced into the first chamber of the balloon catheter; and

(e) creating a fistula through the desired location of the eye.

2. The method of claim 1 wherein the fistula of step (d) is formed through the sclera near the limbus portion of the eye and into the anterior chamber.

3. The method of claim 1 wherein the wound modulating agent is selected from the group consisting of alkylating drugs, antimetabolites and natural alkaloids.

4. The method of claim 3 wherein the wound modulating agent is Mitomycin-C.

5. The method of claim 4 wherein the concentration of Mitomycin-C is 0.001%-0.06%.

6. The method of claim 1 wherein the catheter sheath is introduced into the episcleral space of the eye.

7. The method of claim 1 further comprising, after step (a), anchoring the catheter sheath having a holding means to keep the catheter in place.

8. A method for repairing a failed glaucoma filtration procedure by scar revision, comprising:

(a) introducing a catheter sheath having a holding means to a desired location;

(b) inserting a balloon catheter having a rigid tip portion and a first and second chamber into the catheter sheath;

(c) delivering a wound modulating agent through the second chamber of the balloon catheter to a scar formation;

(d) washing the applied wound modulating agent with a washing solution introduced into the first chamber of the balloon catheter; and

(e) poking a rigid tipped object through the scar formation to create channels through the scar formation.

9. The method of claim 8 further comprising after step (c), introducing a cannula into the first chamber of the balloon catheter.

10. The method of claim 8 wherein the rigid tipped object of step (e) is introduced inside the catheter sheath prior to poking the scar formations.

11. The method of claim 10 wherein the rigid tipped object is introduced into a cannula to cover the rigid tipped object prior to introducing the rigid tipped object into the catheter sheath.

12. The method of claim 8 further comprising, after step (a), anchoring the catheter sheath having a holding means to keep the catheter in place.