System and method for providing hemodynamically optimal pacing

• US 5,891,176 A
• Filed: 10/25/1996
• Issued: 04/06/1999
• Est. Priority Date: 05/09/1996
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Bornzin, Gene A.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/736,891
• Time in Patent Office: 893 Days
• Field of Search: 601/17, 601/18, 601/19, 601/23-25, 601/27
• US Class Current: 607/18
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A system and method for a pacemaker are provided, for monitoring cardiac performance and adjusting a pacing regime to ensure hemodynamically optimal pacing therapy. The pacemaker includes a sensor for measuring a physiological parameter as an indicator of cardiac performance. A processing system dithers various programmable pacing parameters and notes the resulting changes in cardiac performance. The processor analyzes the changes in cardiac performance corresponding to changes in the pacing parameters and selects those parameters resulting in maximum cardiac performance. An activity sensor may be provided to allow the processing system to consider the activity level of a patient when determining a hemodynamically optimal pacing regime.

Claims

1. A cardiac pacemaker for providing optimal pacing therapy to a patient, the pacemaker having a plurality of pacing modes, the pacemaker comprising:

first sensing means for providing a signal indicative of cardiac performance;

pulse generating means for generating stimulation pulses to a patient'"'"'s heart;

exercise detecting means for detecting the exercise state of a patient;

means for determining when the cardiac performance is maximized based on the first sensing means;

processing means for controlling the pulse generating means to operate in the plurality of pacing modes and for determining an optimal pacing mode when the determining means indicates that the cardiac performance is maximized for a current exercise state of the patient; and

means for automatically switching from a current pacing mode to the optimal pacing mode.

2. The pacemaker as recited in claim 1, wherein the pacemaker has a plurality of pacing parameters, wherein the processing means comprises:

means for determining an optimal set of pacing parameters in each pacing mode by adjusting a plurality of pacing parameters until a maximum cardiac performance is obtained;

means for comparing the maximum cardiac performance in each pacing mode; and

means for selecting as the optimal pacing mode that pacing mode which has the maximum cardiac performance.

3. The pacemaker as recited in claim 2, wherein the means for determining the optimal set of pacing parameters comprises:

means for periodically generating a plurality of temporary pacing parameters and for measuring a plurality of changes in cardiac performance as indicated by the first sensor;

means for analyzing the changes in cardiac performance to determine if cardiac performance is improved using any of the plurality of temporary pacing parameters; and

means for adjusting a current set of pacing parameters to an optimal set of the plurality of temporary pacing parameters if cardiac performance is improved.

4. The pacemaker as recited in claim 1, wherein:

the plurality of pacing modes includes an A-V sequential mode;

the processing means includes means for determining an optimal A-V sequential pacing mode; and

the pulse generating means includes means for generating stimulation pulses in the optimal A-V sequential pacing mode.

5. The pacemaker as recited in claim 4, wherein the means for determining the optimal A-V sequential pacing mode comprises:

means for defining a plurality of A-V sequential pacing modes;

means for determining an optimal set of pacing parameters for each of the plurality of A-V sequential pacing modes;

means for comparing the maximum cardiac performance in each pacing mode using the optimal set of pacing parameters; and

means for selecting as the optimal A-V sequential pacing mode that A-V sequential pacing mode which provides a maximum cardiac performance.

6. The pacemaker as recited in claim 5, wherein the A-V sequential modes have a programmable A-V delay and rate, wherein the means for defining a plurality of A-V sequential pacing modes comprises means for controlling the A-V delay and the rate so that one of:

an atrial pacing/ventricular pacing (A-V) mode,

an atrial sensing/ventricular pacing (P-V) mode,

an atrial pacing/ventricular sensing (A-R) mode, or

an atrial sensing/ventricular sensing (P-R) mode is enabled.

7. The pacemaker as recited in claim 1, wherein:

the exercise detecting means comprises means for detecting a plurality of exercise levels of the patient; and

the means for determining an optimal sequential mode of operation further comprises means for determining an optimal pacing mode for the patient at each of the plurality of exercise levels.

8. The pacemaker as recited in claim 1, wherein:

the exercise detecting means includes means for detecting when the patient is in one of a rest state, a wake state, or an exercise state; and

the processing means for determining the optimal pacing mode further includes means for determining an optimal pacing mode while the patient is in one of the rest state, the wake state, or the exercise state.

9. A method of providing hemodynamically optimum pacing therapy in an implantable stimulation device having a plurality of pacing modes, comprising the steps of:

sensing a signal indicative of cardiac performance;

detecting the exercise state of a patient;

generating stimulation pulses with a pulse generator to a patient'"'"'s heart;

controlling the pulse generator to operate in the plurality of pacing modes;

determining an optimal pacing mode when the cardiac performance is maximized while the patient is in a current exercise state; and

automatically switching from a current pacing mode to the optimal pacing mode when cardiac performance is improved by a prescribed amount.

10. The method as recited in claim 9, wherein the implantable stimulation device has a plurality of pacing parameters, wherein the step of determining the optimal pacing mode comprises the steps of:

determining an optimal set of pacing parameters in each of the plurality of pacing modes by adjusting a plurality of pacing

parameters until a maximum cardiac performance is obtained;

comparing the maximum cardiac performance in each pacing mode; and

selecting as the optimal pacing mode that pacing mode which has the maximum cardiac performance.

11. The method as recited in claim 10, wherein the step of determining the optimal set of pacing parameters comprises the steps of:

periodically generating a plurality of temporary pacing parameters;

measuring a plurality of changes in cardiac performance;

determining if cardiac performance is improved using any of the plurality of temporary pacing parameters; and

adjusting a current set of pacing parameters to an optimal set of the plurality of temporary pacing parameters if cardiac performance is improved.

12. The method as recited in claim 9, wherein:

the plurality of pacing modes includes an A-V sequential mode;

the step of determining the optimal pacing mode comprises the step of determining an optimal A-V sequential pacing mode; and

the step of generating stimulation pulses comprises the step of generating stimulation pulses in the optimal A-V sequential pacing mode.

13. The method as recited in claim 12, wherein the step of determining the optimal A-V sequential pacing mode comprises the steps of:

defining a plurality of A-V sequential pacing modes;

determining an optimal set of pacing parameters for each of the plurality of A-V sequential pacing modes;

comparing the maximum cardiac performance in each pacing mode using the optimal set of pacing parameters; and

selecting as the optimal A-V sequential pacing mode that A-V sequential pacing mode which provides a maximum cardiac performance.

14. The method as recited in claim 13, wherein the A-V sequential modes have a programmable A-V delay and rate, wherein the step of defining a plurality of A-V sequential pacing modes comprises the step of controlling A-V delay and rate so that one of:

an atrial pacing/ventricular pacing (A-V) mode,

an atrial sensing/ventricular pacing (P-V) mode,

an atrial pacing/ventricular sensing (A-R) mode, or

an atrial sensing/ventricular sensing (P-R) mode is enabled.

15. The method as recited in claim 9, wherein:

the exercise detection means comprises means for detecting a plurality of exercise levels of the patient; and

the step for determining an optimal sequential mode of operation further comprises the step of determining an optimal pacing mode for the patient at each of the plurality of exercise levels.

16. The method as recited in claim 9, further comprising the steps of:

detecting when the patient is in one of a rest state, a wake state, or an exercise state; and

determining an optimal pacing mode while the patient is in one of the rest state, the wake state, or the exercise state.

17. A dual-chamber implantable stimulation device, comprising:

atrial sensing means for sensing P-waves;

ventricular sensing means for sensing R-waves;

timing means for controlling an atrial escape interval and an A-V time interval;

pulse generator means for generating an atrial stimulation pulse (A-pulse) in the absence of a sensed P-wave within the atrial escape interval, and a ventricular stimulation pulse (V-pulse) in the absence of an R-wave within the A-V time interval;

sensing means for sensing a signal representative of hemodynamic performance;

exercise detection means for detecting a patient'"'"'s level of exercise corresponding to at least one of a rest state, a wake state, or an exercise state;

means for determining an optimal sequential mode of operation corresponding to maximum hemodynamic performance based on the patient'"'"'s level of exercise; and

means for adjusting the pulse generator means to generate stimulation pulses in the optimal sequential mode of operation.

18. The dual-chamber implantable stimulation device as recited in claim 17, wherein:

the sequential mode of operation comprises one of an

atrial pacing/ventricular pacing (A-V) mode, an

atrial sensing/ventricular pacing (P-V) mode, an

atrial pacing/ventricular sensing (A-R) mode, or

an atrial sensing/ventricular sensing (P-R) mode.

19. The implantable dual-chamber stimulation device as recited in claim 17, wherein the means for determining an optimal sequential mode of operation comprises:

means for determining an optimal atrial escape interval; and

means for determining an optimal atrial contraction-to-ventricular contraction time interval.

20. The dual-chamber implantable stimulation device as recited in claim 19, wherein the means for determining the optimal sequential mode of operation corresponding to the rest state comprises:

means for determining the patient'"'"'s typical rate over a period of time corresponding to the rest state; and

means for adjusting the atrial contraction-to-ventricular contraction time interval until a maximum hemodynamic performance is determined.

21. The dual-chamber implantable stimulation device as recited in claim 20, further comprising:

means for detecting a period of time corresponding to the rest state.

22. The dual-chamber stimulation device as recited in claim 20, further comprising:

means for determining an initial rate based on the patient'"'"'s level of exercise; and

means for adjusting the atrial contraction-to-ventricular contraction time interval until the maximum performance is determined.

23. The dual-chamber implantable stimulation device as recited in claim 22, wherein the means for determining the initial rate based on the level of exercise of the patient, further comprises:

means for rapidly adjusting the atrial escape interval based on the exercise level detection means until a steady state of exercise is achieved; and

means for fine tuning the atrial escape interval for the maximum hemodynamic performance as sensed by the sensing means once steady state of exercise is achieved.

24. The dual-chamber implantable stimulation device as recited in claim 22, wherein the means for determining the initial rate based on the level of exercise of the patient, further comprises:

means for re-adjusting the atrial escape interval for the maximum hemodynamic performance after the adjusting means adjust the A-V delay for maximum hemodynamic performance.