Ion-implanted protein-coated intralumenal implants

• US 5,891,192 A
• Filed: 05/22/1997
• Issued: 04/06/1999
• Est. Priority Date: 05/22/1997
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Suzuki, Yoshiaki, Murayama, Yuichi, Iwaki, Masaya, Vinuela, Fernando
• Primary Examiner(s): Isabella, David J.
• Application Number:
  US08/861,994
• Time in Patent Office: 684 Days
• Field of Search: 623/1, 623/2, 623/11, 623/12, 623/66, 428/410, 427/2
• US Class Current: 623/1.48
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/122 Collagen
• CPC Class Codes: A61L 33/126 Fibrin
• CPC Class Codes: A61L 33/128 Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

Ion-implanted protein-coated occlusion coils are described which have essentially the same dimensions as untreated coils and exhibit altered surface properties, e.g., thrombogenicity, endothelial cellular migration and adhesion, relative to untreated coils thus making them particularly useful in treating wide-necked brain aneurysms.

Claims

1. An intralumenal implant comprising a body of a biocompatible material and an ion-implanted protein coating on the body.

2. The implant of claim 1 wherein the biocompatible material is selected from the group consisting of a metal, a bioabsorbable polymer, a bioabsorbable copolymer, a nonbioabsorbable polymer, and a nonbioabsorbable copolymer.

3. The implant of claim 2 wherein the implant is selected from the group consisting of an occlusion coil and a stent.

4. An occlusion coil comprising a coil of a biocompatible material and an ion-implanted protein coating on the coil.

5. The coil of claim 4 wherein the biocompatible material is selected from the group consisting of a metal, a bioabsorbable polymer, a bioabsorbable copolymer, a nonbioabsorbable polymer, and a nonbioabsorbable copolymer.

6. The coil of claim 4 wherein the protein is a cell adhesion protein.

7. The coil of claim 6 wherein the biocompatible material is a metal and the cell adhesion protein is selected from the group consisting of collagen, fibronectin, vitronectin, laminin, and fibrinogen.

8. The coil of claim 4 wherein the ion is selected from the group consisting of He⁺, C⁺, N⁺, Ne⁺, Na⁺, K⁺, N₂⁺, O₂⁺, Kr⁺, H⁺, and Ar⁺.

9. The coil of claim 6 wherein the ion is selected from the group consisting of He⁺, C⁺, N⁺, Ne⁺, Na⁺, K⁺, N₂⁺, O₂⁺, Kr⁺, H⁺, and Ar⁺.

10. The coil of claim 7 wherein the ion is Ne⁺.

11. A method for occluding a site within a mammalian body lumen comprising placing one or more ion-implanted protein-coated occlusion coils at said site.

12. The method of claim 11 wherein the protein is a cell adhesion protein.

13. The method of claim 12 wherein the protein is selected from the group consisting of collagen, fibronectin, vitronectin, laminin, and fibrinogen.

14. The method of claim 11 wherein the ion is selected from the group consisting of He⁺, C⁺, N⁺, Ne⁺, Na⁺, K⁺, N₂⁺, O₂⁺, Kr⁺, H⁺, and Ar⁺.

15. The method of claim 12 wherein the ion is selected from the group consisting of He⁺, C⁺, N⁺, Ne⁺, Na⁺, K⁺, N₂⁺, O₂⁺, Kr⁺, H⁺, and Ar⁺.

16. The method of claim 13 wherein the ion is Ne⁺.

17. The method of claim 11 wherein the mammal is a human and the body lumen is a wide-necked brain aneurysm.

18. A method for making an ion-implanted protein-coated intralumenal implant comprising:

a) providing an implant body of a biocompatible material;

b) coating the body with a protein to form a protein-coated implant body; and

c) subjecting the protein-coated implant body to ion implantation.

19. The method of claim 18 wherein the fluency of ions used in step c) is in the range of about 1×

10¹⁴ and 1×

10¹⁸ ions/cm² and the accelerating energy used in step c) is in the range of about 10 and 1000 keV.

20. The method of claim 19 wherein the implant body is an occlusion coil or a stent and the protein is a cell adhesion protein.