Antimicrobial composition containing a C.sub.3 -C.sub.6 alcohol
First Claim
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1. A mouthwash composition comprising:
- thymol in an amount from about 0.001% to about 0.35% w/v,eucalyptol in an amount from about 0.001% to about 0.20% w/v,menthol in an amount from about 0.001% to about 0.3% w/v,methyl salicylate in an amount from about 0.001% to about 0.3% w/v,ethanol in an amount from about 20% v/v to about 25% v/v,a buffer system comprising sodium benzoate and benzoic acid in an amount from about 0.01% to about 4.0% w/v to achieve a pH of about 3.5 to about 9.0,a poly(oxyethylene)-poly(oxypropylene) block copolymer in an amount from about 0.01% to about 0.8% w/v, andan alcohol having 3 to 6 carbons in an amount from about 0.01% to about 10% w/v;
wherein the composition has an R-factor of about 1 to about 1.26.
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Abstract
An antimicrobial composition containing an alcohol having 3 to 6 carbon atoms which effectively increases antimicrobial activity and particularly a mouthwash composition that is useful in the prevention and reduction of bad breath, plaque and related gum diseases having an antimicrobially effective amount of one or more active essential oils; from about 0.01% to about 30.0% v/v of an alcohol having 3 to 6 carbon atoms; optionally, ethanol; at least one surfactant; and water. The actives not only provide enhanced efficacy but are completely solubilized, thus providing an aesthetically appealing product.
99 Citations
13 Claims
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1. A mouthwash composition comprising:
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thymol in an amount from about 0.001% to about 0.35% w/v, eucalyptol in an amount from about 0.001% to about 0.20% w/v, menthol in an amount from about 0.001% to about 0.3% w/v, methyl salicylate in an amount from about 0.001% to about 0.3% w/v, ethanol in an amount from about 20% v/v to about 25% v/v, a buffer system comprising sodium benzoate and benzoic acid in an amount from about 0.01% to about 4.0% w/v to achieve a pH of about 3.5 to about 9.0, a poly(oxyethylene)-poly(oxypropylene) block copolymer in an amount from about 0.01% to about 0.8% w/v, and an alcohol having 3 to 6 carbons in an amount from about 0.01% to about 10% w/v;
wherein the composition has an R-factor of about 1 to about 1.26. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A mouthwash composition comprising:
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thymol in an amount from about 0.04% to about 0.07% w/v, eucalyptol in an amount from about 0.085% to about 0.1% w/v, menthol in an amount from about 0.035% to about 0.05% w/v, methyl salicylate in an amount from about 0.04% to about 0.07% w/v, ethanol in an amount from about 20% v/v to about 22.7% v/v, a buffer system comprising sodium benzoate and benzoic acid in an amount from about 0.01% to about 4.0% w/v to achieve a pH of about 3.5 to about 9.0, a poly(oxyethylene)-poly(oxypropylene) block copolymer in an amount from about 0.01% to about 0.8% w/v, and an alcohol having 3 to 6 carbons in an amount from about 0.01% to about 10% w/v;
wherein the composition has an R-factor of about 1 to about 1.26.
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Specification
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Current AssigneeMcNeil-PPC Incorporated (Johnson & Johnson)
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Original AssigneeWarner-Lambert Company (Pfizer Inc.)
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InventorsVolpe, Frank, Carlin, Edward, Martin, Alain, Pan, Pauline, Buch, R. Michael
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Primary Examiner(s)Rose, Shep K.
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Application NumberUS08/722,450Time in Patent Office908 DaysField of Search424/49-58US Class Current424/49CPC Class CodesA61K 8/34 AlcoholsA61K 8/347 PhenolsA61K 8/37 Esters of carboxylic acidsA61K 8/498 having 6-membered rings or ...A61Q 11/00 Preparations for care of th...
