Treatment of arthritic disease induced by infectious agents
First Claim
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1. A method of treating rheumatoid arthritis or arthritis symptoms induced by infectious agents of an arthritis patient comprising the steps ofadministering to a rheumatoid arthritis patient or a patient suffering from arthritis symptoms induced by infectious agents an amount of the following compound effective to reduce arthritis symptoms:
- ##STR3## wherein X1 and X2 are each selected from the group consisting of hydrogen and acyl;
wherein Y1 and Y2 can be H, or one can be 0=arkyl or 0=alkyl and can have a β
or α
configuration;
Z1 ═
Z2 ═
H or Z1 and Z2 together are CH2 ; and
wherein R is an alkyl, hydroxyalkyl or fluoroalkyl group, or R may represent the following side chain;
##STR4## wherein (a) may have an S or R configuration, R1 represents hydrogen, hydroxy or O-acyl, R2 and R3 are each selected from the group consisting of alkyl, hydroxyalkyl and fluoralkyl, or, when taken together represent the group-(CH2),-wherein m is an integer having a value of from 2 to 5, R4 is selected from the group consisting of hydrogen, hydroxy, fluorine, O-acyl, alkyl, hydroxyalkyl and fluoralkyl, wherein if R5 is hydroxyl or fluoro, R4 must be hydrogen or alkyl, R5 is selected from the group consisting of hydrogen, hydroxy, fluorine, alkyl, hydroxyalkyl and fluoroalkyl, or R4 and R5 taken together represent double-bonded oxygen, R6 and R7 taken together form a carbon-carbon double bond, R8 may be H or CH3, and wherein n is an integer having a value of from 1 to 5, and wherein the carbon at any one of positions 20, 22, or 23 in the side chain may be replaced by an O, S, or N atom.
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Abstract
A method of treating arthritis symptoms induced by an infectious agent of an arthritis patient comprising administering to an arthritis patient an amount of vitamin D compound effective to reduce symptoms and observing a reduction in symptoms is disclosed.
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Citations
14 Claims
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1. A method of treating rheumatoid arthritis or arthritis symptoms induced by infectious agents of an arthritis patient comprising the steps of
administering to a rheumatoid arthritis patient or a patient suffering from arthritis symptoms induced by infectious agents an amount of the following compound effective to reduce arthritis symptoms: - ##STR3## wherein X1 and X2 are each selected from the group consisting of hydrogen and acyl;
wherein Y1 and Y2 can be H, or one can be 0=arkyl or 0=alkyl and can have a β
or α
configuration;
Z1 ═
Z2 ═
H or Z1 and Z2 together are CH2 ; andwherein R is an alkyl, hydroxyalkyl or fluoroalkyl group, or R may represent the following side chain;
##STR4## wherein (a) may have an S or R configuration, R1 represents hydrogen, hydroxy or O-acyl, R2 and R3 are each selected from the group consisting of alkyl, hydroxyalkyl and fluoralkyl, or, when taken together represent the group-(CH2),-wherein m is an integer having a value of from 2 to 5, R4 is selected from the group consisting of hydrogen, hydroxy, fluorine, O-acyl, alkyl, hydroxyalkyl and fluoralkyl, wherein if R5 is hydroxyl or fluoro, R4 must be hydrogen or alkyl, R5 is selected from the group consisting of hydrogen, hydroxy, fluorine, alkyl, hydroxyalkyl and fluoroalkyl, or R4 and R5 taken together represent double-bonded oxygen, R6 and R7 taken together form a carbon-carbon double bond, R8 may be H or CH3, and wherein n is an integer having a value of from 1 to 5, and wherein the carbon at any one of positions 20, 22, or 23 in the side chain may be replaced by an O, S, or N atom. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- ##STR3## wherein X1 and X2 are each selected from the group consisting of hydrogen and acyl;
Specification