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Anti-viral compound

  • US 5,891,874 A
  • Filed: 06/04/1997
  • Issued: 04/06/1999
  • Est. Priority Date: 06/05/1996
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula I ##STR35## wherein:

  • a is 1, 2 or 3;

    each R is independently halo, cyano, amino, halo(C1 -C4)alkyl, di(C1 -C4)alkylamino, azido, C1 -C6 alkyl, carbamoyl, carbamoyloxy, carbamoylamino, C1 -C4 alkoxy, C1 -C4 alkylthio, C1 -C4 alkylsulfinyl, C1 -C4 alkylsulfonyl, pyrrolidino, piperidino or morpholino;

    R0 is hydrogen, halo, C1 -C4 alkyl or C1 -C4 alkoxy;

    R1 is halo, cyano, hydroxy, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl or methylsulfonyl;

    R2 is hydrogen, amino or --NHC(O) (C1 -C6 alkyl);

    R3 is dimethylamino, C1 -C10 alkyl, halo(C1 -C6)alkyl, C3 -C7 cycloalkyl, substituted C3 -C7 cycloalkyl, phenyl, substituted phenyl, naphthyl, thienyl, thiazolidinyl, furyl, pyrrolidino, piperidino, morpholino or a group of the formula;

    ##STR36## R4 and R5 are independently hydrogen or C1 -C4 alkyl;

    with the proviso that when R is in the 2- or 6-position, then R cannot be halo, cyano, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl or methylsulfonyl;

    or a pharmaceutically acceptable salt thereof.

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