Gain control for a periodic signal and method regarding same

• US 5,895,360 A
• Filed: 06/26/1996
• Issued: 04/20/1999
• Est. Priority Date: 06/26/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Neisz, Johann J., Christopherson, Mark A.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US08/673,718
• Time in Patent Office: 1,028 Days
• Field of Search: 128/716, 128/718, 128/721, 128/725, 607/42, 600/529, 600/531, 600/534, 600/538
• US Class Current: 600/529
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control

Abstract

A gain control method for providing a gain controlled signal representative of a periodic physiological parameter of a patient includes providing a signal characteristic of the periodic physiological parameter. The periodic physiological parameter includes a plurality of periodic cycles. Gain of the signal is updated only once per periodic cycle following detection of a periodic event. The updating is performed by monitoring an amplitude of the signal between detection of periodic events and comparing the amplitude to a gain control amplitude threshold. Gain of the signal is updated as a function of the comparison. Further, gain is updated following expiration of a predetermined period of time if a periodic event is not detected within the predetermined period of time. The physiological parameter may be respiratory effort. An apparatus for providing such gain control is also provided.

Claims

1. A gain control method for providing a gain controlled signal representative of a periodic physiological parameter of a patient, the method comprising the steps of:

measuring the physiological parameter;

providing a signal characteristic of the periodic physiological parameter, the periodic physiological parameter including a plurality of periodic cycles;

updating gain of the signal, exponentially such that the percentage change between gain steps is substantially constant over gain changes, only once per periodic cycle following detection of a periodic event.

2. The method according to claim 1, in which the updating step includes the steps of:

monitoring an amplitude of the signal between detection of periodic events;

comparing the amplitude of the monitored signal to a gain control amplitude threshold; and

updating gain of the signal as a function of the comparison.

3. The method according to claim 2, in which the updating step further includes the steps of:

incrementing the gain of the signal if the gain control amplitude threshold is exceeded by the monitored signal; and

decrementing the gain of the signal if the gain control amplitude threshold is not exceeded by the monitored signal.

4. The method according to claim 1, in which the updating step further includes the step of updating gain following expiration of a predetermined period of time if a periodic event is not detected within the predetermined period of time.

5. The method according to claim 4, in which the predetermined period of time is determined as a function of a normal time period for a periodic cycle to occur.

6. The method according to claim 1, in which the physiological parameter is respiratory effort of the patient, and further in which the detection step includes the steps of:

monitoring at least one characteristic of the signal representative of respiratory effort; and

detecting the periodic event as a function of the at least one monitored characteristic and at least one characteristic threshold.

7. The method according to claim 6, in which the monitoring step includes monitoring at least one of slope and amplitude of the signal, and further in which the detecting step includes detecting a periodic event as a function of a comparison of the monitored slope and amplitude to slope and amplitude thresholds.

8. The method according to claim 7, in which the periodic event is inspiration offset, in which the monitoring step includes sampling the amplitude of the respiratory effort signal and generating slope values representative of the respiratory effort signal based on the amplitude samples, and further in which the detection of inspiration offset includes the steps of:

comparing the slope values to a predetermined slope value offset threshold in a first comparing step;

comparing the amplitude of sampled respiratory effort waveform to a predetermined amplitude offset threshold in a second comparison step; and

detecting inspiration offset as a function of the first comparison step and the second comparison step.

9. The method according to claim 8, in which the detection of inspiration offset further includes validating the detected inspiration offset by comparing the amplitude of the sampled respiratory waveform to a validating offset threshold.

10. The method according to claim 1, in which the method further includes the step of initializing gain for the signal to an intermediate level to start the signal with a peak amplitude near an amplitude threshold used to update gain.

11. A gain control method for providing a gain controlled respiratory effort signal of a patient, the method comprising the steps of:

providing a signal characteristic of the respiratory effort of a patient, the respiratory effort of a patient including a plurality of respiratory cycles;

detecting a periodic event which includes one of inspiration offset and inspiration onset; and

updating gain of the signal only once per periodic cycle following detection of a periodic event.

12. The method according to claim 11, in which the detection of a periodic event includes detection of the periodic event as a function of one or more signal thresholds.

13. The method according to claim 11, further including the step of defining a refractory period as a function of the detected periodic event during which gain of the signal is maintained at the same level.

14. The method according to claim 11, in which the detection of the periodic event includes the steps of:

monitoring at least one characteristic of the respiratory effort signal to detect the periodic event; and

detecting the periodic event as a function of the characteristic of the respiratory effort signal.

15. The method according to claim 14, in which the periodic event is inspiration offset, in which the method further includes the step of defining a refractory period as a function of the detected inspiration offset, and further in which the updating step includes updating gain of the signal following an inspiration offset detected outside of the refractory period.

16. The method according to claim 15, in which the monitoring step includes monitoring at least one of slope and amplitude of the signal, and further in which the detecting step includes detecting inspiration offset as a function of a comparison of the monitored slope and amplitude to slope and amplitude thresholds.

17. The method according to claim 16, in which the monitoring step includes sampling the amplitude of the respiratory effort signal and generating slope values representative of the respiratory effort signal based on the amplitude samples, and further in which the detection of inspiration offset includes the steps of:

comparing the slope values to a predetermined slope value offset threshold in a first comparison step;

comparing the amplitude of sampled respiratory effort waveform to a predetermined amplitude offset threshold in a second comparison step; and

detecting inspiration offset as a function of the first comparison step and the second comparison step.

18. The method according to claim 17, in which the detection of inspiration offset further includes validating the detected inspiration offset by comparing the amplitude of the sampled respiratory signal to a validating offset threshold.

19. The method according to claim 13, in which the refractory period defining step includes the step of defining the refractory period as a function of at least one of a detected inspiration offset, average respiratory period, and average time of inspiration.

20. The method according to claim 19, further comprising defining the refractory period as a fraction of the average respiratory period.

21. The method according to claim 20, further comprising defining the fraction in the range between 0.1 to about 0.8.

22. The method according to claim 19, further comprising defining the average respiratory period as a weighted sum average respiratory period.

23. The method according to claim 19, including the step of basing the average time of inspiration on a statistical average.

24. The method according to claim 11, in which the updating step further includes the step of updating gain following expiration of a predetermined time period even if a periodic event is not detected.

25. The method according to claim 24, including the step of basing the predetermined time period on an average respiratory time period.

26. The method according to claim 11, in which the periodic event is inspiration offset, and further in which the updating step includes the steps of:

monitoring an amplitude of the signal between detection of inspiration offsets;

comparing the amplitude of the monitored signal to a gain control amplitude threshold; and

updating gain of the signal as a function of the comparison.

27. A gain control apparatus for providing a gain controlled signal representative of a periodic physiological parameter of a patient, the physiological parameter including a plurality of periodic cycles, the apparatus comprising:

means for receiving a signal characteristic of the periodic physiological parameter;

means for detecting a periodic event of the signal as a function of at least one predetermined threshold;

means for updating gain of the signal, exponentially such that the percentage change between gain steps is substantially constant over gain changes, only once during each periodic cycle following detection of a periodic event.

28. The apparatus according to claim 27, in which the updating means includes:

means for monitoring an amplitude of the signal between detection of periodic events;

means for comparing the amplitude of the monitored signal to a gain control amplitude threshold; and

means for incrementing and decrementing gain of the signal as a function of the comparison means.

29. The apparatus according to claim 28, in which the updating means further includes:

means for incrementing the gain of the signal if the gain control amplitude threshold is exceeded by the monitored signal; and

means for decrementing the gain of the signal if the gain control amplitude threshold is not exceeded by the monitored signal.

30. The apparatus according to claim 27, in which the updating means includes a timer and means for updating gain following expiration of a predetermined period of time tracked by the timer if a periodic event is not detected within the predetermined period of time.

31. The apparatus according to claim 30, further comprising means for determining the predetermined period of time as a function of a normal time period for a periodic cycle to occur.

32. The apparatus according to claim 27, in which the physiological parameter is respiratory effort of the patient including a plurality of respiratory cycles, and further in which the detection means includes:

means for monitoring at least one characteristic of the signal representative of respiratory effort; and

means for detecting a periodic event as a function of the at least one monitored characteristic and the at least one predetermined threshold.

33. The apparatus according to claim 32, in which the monitoring means includes means for monitoring at least one of slope and amplitude of the signal, and further in which the detecting means includes means for detecting a periodic event as a function of a comparison of the monitored at least one of slope and amplitude to at least one of slope and amplitude thresholds.

34. The apparatus according to claim 33, in which the periodic event is one of inspiration offset and inspiration onset.

35. The apparatus according to claim 27, further including means for initializing gain for the signal to an intermediate level to start the signal with a peak amplitude near an amplitude threshold used to update gain.

36. The apparatus according to claim 27, further including means for defining a refractory period as a function of the detected periodic event, and further in which the updating means includes means for updating gain of the signal only following detection of a periodic event detected outside of the refractory period.

37. The apparatus according to claim 36, in which the refractory period defining means includes means for defining the refractory period as a function of at least one of a detected inspiration offset, average respiratory period, and average time of inspiration.

38. The apparatus according to claim 27, in which the gain controlled signal is provided to a therapy apparatus for treating the patient, the therapy apparatus including:

means for receiving the gain controlled signal;

means for monitoring the gain controlled signal by comparison to at least one threshold; and

means for providing therapy to the patient in response to the monitoring means.