Iontophoresis patch/controller interconnection using a conductive elastomer to provide noise-free electrical contact between patch and controller

• US 5,895,369 A
• Filed: 04/04/1997
• Issued: 04/20/1999
• Est. Priority Date: 09/30/1994
• Status: Expired due to Term

• Current Assignee: Vyteris, Inc.
• Original Assignee: Becton, Dickinson & Co
• Inventors: Flower, Ronald J.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US08/825,976
• Time in Patent Office: 746 Days
• Field of Search: 604/20-21, 607/149, 607/152, 439/67, 439/260, 439/267, 439/495, 439/725, 439/909
• US Class Current: 604/20
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

An iontophoretic drug delivery system having a patch including a medicament containing surface, and a controller having circuits which supply electric current to effect the iontophoretic drug delivery. The patch is detachably coupled to the controller and includes a plurality of spaced-apart electrical contacts. The controller includes an elastomeric connector which is made of alternating sections of electrically conductive and electrically non-conductive material. The electrically conductive material of the elastomeric connector is coupled to the controller circuiting. During transcutaneous drug delivery, the patch is connected to the controller such that the electrically conductive sections of the elastomeric connector are also coupled to respective spaced-apart electrical contacts of the patch so that the controller can control the rate and duration of the drug delivery.

Claims

1. An iontophoretic drug delivery system for delivering medication to an applied area of a patient comprising:

an iontophoretic drug delivery patch for placement against the skin of a patient, the iontophoretic drug delivery patch including a flexible support base having thereon a medicament, at least first and second electrodes, and an integrally formed tab supporting a plurality of spaced-apart electrical contacts, at least a first electrical contact and a second electrical contact of the plurality of spaced-apart electrical contacts being respectively electrically coupled to the at least first and second electrodes; and

a controller having an outer housing and including a portion mateable with the flexible tab of the iontophoretic drug delivery patch, the controller housing including therein electronic components for controlling current provided to the electrodes of the iontophoretic drug delivery patch, at least two controller contacts, and an elastomeric connector, the elastomeric connector being disposed between and electrically in contact with the at least two contacts of the controller and the at least first and second electrical contacts of the iontophoretic drug delivery patch when the controller is mated with the iontophoretic drug delivery patch.

2. An iontophoretic drug delivery system as defined by claim 1, wherein the elastomeric connector comprises alternating sections of electrically conductive and electrically insulative material.

3. An iontophoretic drug delivery system as defined by claim 1, wherein the elastomeric connector enables a substantially constant current flow from the controller to the iontophoretic drug delivery patch.

4. An iontophoretic drug delivery system as defined by claim 1, wherein the elastomeric connector includes at least first and second electrically conductive sections and a first electrically insulative section, the first electrically insulative section preventing a current flow between the first conductive section and the second conductive section.

5. An iontophoretic drug delivery system as defined by claim 1, wherein the elastomeric connector includes a plurality of spaced-apart transverse conductive sections, at least one of the plurality of spaced-apart electrical contacts engaging at least one of the plurality of conductive sections so as to electrically couple a corresponding spaced-apart electrical contact of the iontophoretic drug delivery patch to the controller.

6. An iontophoretic drug delivery system as defined by claim 1, wherein the controller housing includes a printed circuit board having a plurality of spaced-apart electrical contacts, the elastomeric connector being electrically coupled to at least one of the plurality of spaced-apart electrical contacts of the printed circuit board, the elastomeric connector electrically coupling the at least one of the plurality of spaced-apart electrical contacts of the iontophoretic drug delivery patch to the at least one of the plurality of spaced-apart electrical contacts of the printed circuit board.

7. An iontophoretic drug delivery system as defined by claim 1, wherein the elastomeric connector includes a first electrically conductive section and a first electrically insulative section.

8. An iontophoretic drug delivery system as defined by claim 1, wherein the elastomeric connector comprises alternating sections of electrically insulative inert material and electrically conductive inert material to substantially eliminate corrosion and/or electrolysis at the connector assembly.

9. An iontophoretic drug delivery system for delivering medication to an applied area of a patient comprising:

an iontophoretic drug delivery patch for placement against the skin of the patient, the iontophoretic drug delivery patch including a medicament, at least first and second electrodes and a flexible tab supporting a plurality of spaced-apart electrical contacts, at least a first electrical contact and a second electrical contact of the plurality of spaced-apart electrical contacts being respectively electrically coupled to the at least first and second electrodes; and

a controller having an outer housing and including a portion mateable with the flexible tab of the iontophoretic drug delivery patch, the controller housing including therein electronic components for controlling currents provided to the electrodes of the iontophoretic drug delivery patch, at least two controller contacts, and an elastomeric connector, the elastomeric connector including a substantially compliant electrically insulative material having first and second surfaces, the elastomeric connector also including a plurality of conductive plugs, each of the plurality of conductive plugs extending through the electrically insulative material from the first surface to the second surface such that the conductive plugs are only exposed on the first and second surfaces of the insulative material and are otherwise completely surrounded by the insulative material, the elastomeric connector being disposed between and electrically in contact with the at least two contacts of the controller and the at least first and second electrical contacts of the iontophoretic drug delivery patch, and wherein the controller housing includes an external actuator for selectively mating said patch contacts and said elastomeric connector when the controller is mated with the iontophoretic drug delivery patch.

10. An iontophoretic drug delivery system as defined by claim 9, the plurality of conductive sections being disposed within the electrically insulative material so as to electrically couple at least one of the plurality of conductive sections with at least one of the plurality of spaced-apart electrical contacts of the iontophoretic drug delivery patch when the controller is mated thereto.

11. An iontophoretic drug delivery system as defined by claim 9, wherein the electrically insulative material and the conductive plugs are made of inert materials to substantially eliminate corrosion and/or electrolysis at the connector assembly.

12. An iontophoretic drug delivery controller, the iontophoretic drug delivery controller being mateable with an iontophoretic drug delivery patch having at least first and second electrodes and a plurality of spaced-apart electrical contacts, the iontophoretic drug delivery controller substantially manipulating the delivery of a medicament retained by the iontophoretic drug delivery patch, the iontophoretic drug delivery controller comprising an outer housing including a portion mateable with said patch and having therein:

a printed circuit board having a plurality of spaced-apart electrical contacts electrically connected to electrical components for manipulating drug delivery; and

an elastomeric connector including a plurality of spaced-apart transverse conductive sections, the elastomeric connector being electrically coupled to the spaced-apart electrical contacts of the printed circuit board, the plurality of spaced-apart electrical contacts of the printed circuit board being oriented so as to substantially contact correspondingly spaced conductive sections of the elastomeric connector, the elastomeric connector permitting the plurality of spaced-apart electrical contacts of the drug delivery patch to be substantially simultaneously coupled thereto;

and wherein the controller housing includes an external actuator for selectively mating said patch contacts and said elastomeric connector.

13. In combination:

an iontophoretic drug delivery patch having a medicament-containing portion and a controller-interconnection portion, said controller-interconnection portion having a plurality of electrical contacts; and

a controller having an outer housing including a portion mateable with said patch controller-interconnection portion and having therein electronic components for regulating current, the controller being detachably mated with the iontophoretic drug delivery patch, the controller housing including an elastomeric connector having a plurality of conductive portions electrically coupled to the electronic components of the controller housing, the plurality of conductive portions of the elastomeric connector being electrically coupled to the plurality of electrical contacts of the iontophoretic drug delivery patch, and wherein the controller housing includes an external actuator for selectively mating said patch contacts and said elastomeric connector.