Multi-phasic microphotodiode retinal implant and adaptive imaging retinal stimulation system

• US 5,895,415 A
• Filed: 06/06/1995
• Issued: 04/20/1999
• Est. Priority Date: 06/06/1995
• Status: Expired due to Term

• Current Assignee: Pixium Vision SA
• Original Assignee: Optobionics Corporation
• Inventors: Chow, Alan Y., Chow, Vincent
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/465,766
• Time in Patent Office: 1,414 Days
• Field of Search: 607/54, 607/116, 607/148, 607/53, 623/4
• US Class Current: 607/54
• CPC Class Codes: A61F 9/08 Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/36046 of the eye

Abstract

An artificial retina device and a method for stimulating and modulating its function is disclosed. The artificial retina device is comprised of plural multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. One device, called a MMRI-4, transduces light into electric currents to stimulate the retina. The four microphotodiode subunits of the MMRI-4 are oriented so that each flattened sides of the MMRI-4 has two subunits in a PiN configuration and two subunits in a NiP configuration. By projecting real or computer controlled visible light images, and computer controlled infrared light images or illumination, simultaneously or in rapid alternation onto the MMRI-4s, the nature of induced retinal images may be modulated and improved. An Adaptive Imaging Retinal Stimulation System (AIRES), with a Projection and Tracking Optical System (PTOS), which may be worn as a headset is used for this purpose, and is also disclosed. Color images may even be induced by programming the stimulating pulse durations and frequencies of the AIRES system.

Claims

1. A microscopic retinal implant for electrically inducing formed vision in the eye, comprising a PiN microphotodiode having a P-Side and an N-Side, where the P side of the implant has a light filter layer that selectively permits a selected bandwidth of the ultraviolet, visible, and infrared spectrum to pass, and where the N-side of the implant has a light filter layer that selectively permits a selected bandwidth of the ultraviolet, visible, and infrared spectrum to pass, whereby the retinal implant can stimulate the retina regardless of whether the P-side or the N-side is oriented toward light incident to the eye.

2. The microscopic retinal implant of claim 1 wherein the N-side and the P-side filter layers selectively permit substantially the same bandwidth to pass.

3. The microscopic implant of claim 2 wherein the N-side light filter layer is a dielectric filter that allows 740 nm to 900 nm to pass.

4. The microscopic implant of claim 3 wherein the P-side light filter layer is a dielectric filter that allows 740 nm to 900 nm to pass.

5. The microscopic implant of claim 2 wherein the N-side light filter layer is a dielectric filter that allows 400 nm to 740 nm to pass.

6. The microscopic implant of claim 5 wherein the P-side light filter layer is a dielectric filter that allows 400 nm to 740 nm to pass.

7. The microscopic retinal implant of claim 1 wherein the N-side and the P-side filter layers selectively permit substantially different bandwidth to pass.

8. The microscopic implant of claim 7 wherein the N-side light filter layer is a dielectric filter that allows 740 nm to 900 nm to pass.

9. The microscopic implant of claim 8 wherein the P-side light filter layer is a dielectric filter that allows 400 nm to 740 nm to pass.

10. The microscopic implant of claim 7 wherein the N-side light filter layer is a dielectric filter that allows 400 nm to 740 nm to pass.

11. The microscopic implant of claim 10 wherein the P-side light filter layer is a dielectric filter that allows 740 nm to 900 nm to pass.

12. The microscopic retinal implant of claim 1 wherein the PiN microphotodiode contains (1) a P-electrode made of P-doped polysilicon, (2) a P-side light filter dielectric layer, (3) a P+ layer, (4) an intrinsic layer, (5) a N-type silicon substrate, (6) a N+ layer, (7) a N-side light filter dielectric layer, and (8) a N-electrode made of a N-doped polysilicon.

13. The microscopic retina implant of claim 12 wherein the implant further includes a first electrical contact pad that establishes electrical contact between the P-electrode and the P+ layer, and a second electrical contact pad that establishes electrical contact between the N-electrode and the N+ layer.

14. The microscopic retinal implant of claim 12 wherein, the P-electrode projects outwardly from the surface of the implant.

15. The microscopic retinal implant of claim 14 wherein, the N-electrode projects outwardly from the surface of the implant.

16. The microscopic retinal implant of claim 15 wherein, each of the P-electrode and N-electrode projects from about 1 micron to about 200 microns.

17. The microscopic retinal implant of claim 16 wherein, each of the P-electrode and N-electrode projects from about 2 micron to about 100 microns.

18. The microscopic retinal implant of claim 12 wherein, the N-electrode projects outwardly from the surface of the implant.

19. The microscopic implant of claim 1 wherein the implant includes two of said PiN microphotodiodes, each of the microphotodiodes having an opposite orientation from the other such that when implanted in the eye, the P-side of one microphotodiode will face incident light, and the N-side of the other microphotodiode will face incident light.

20. A method of restoring formed vision to a patient having retinal damage, comprising implanting plural implants into the patient'"'"'s eye adjacent the retina, each implant comprising a PiN microphotodiode having a P-side and an N-side, where the P side of the implant has a light filter layer that selectively permits a selected bandwidth of the ultraviolet, visible, and infrared spectrum to pass, and where the N-side of the implant has a light filter layer that selectively permits the a selected bandwidth of the ultraviolet, visible, and infrared spectrum to pass, whereby the retinal implant can stimulate the retina regardless of whether the P-side or the N-side is oriented toward light incident to the eye so that the patient can perceive visual forms.

21. The method of claim 20 where the P side of each implant has a light filter layer that selectively permits only visible light to pass, and where the N-side of each implant has a light filter layer that selectively permits only infrared light to pass.

22. The method of claim 21 wherein a population of such implants are implanted in the "subretinal space" between the outer and inner retina in the eye such that, randomly, about half of them (i.e. the first subpopulation) will be oriented so that the P sides face light incident to the eye, and about half (i.e the second subpopulation) will be oriented so that their N sides face incident light to the eye.

23. The method of claim 22 wherein the first subpopulation of microscopic implants convert energy from incoming visible light into small electrical currents to stimulate the sensation of light detail in the eye to produce formed vision, and the second subpopulation converts infrared light-induced electrical current to stimulate the retina with dark current to produce dark details.

24. The method of claim 23 wherein infrared light is introduced into the eye by an externally-worn unit containing an IR-capable image-producing device, whereby in darkness IR illumination is the predominate power source and powers the second subpopulation, stimulating the visual sensation of dark details.

25. The method of claim 24 wherein said IR-capable image-producing device is also visible-light capable wherein under conditions displaying light and dark details, a current will be induced in the first subpopulation by ambient visible light, and a current is induced in the second subpopulation by IR light, producing a combined perception of light and dark details.

26. The method of claim 25 wherein said externally-worn unit further includes an imaging CCD camera to capture real-time images, and further includes computer means to digitize those images and transmit those images to said image-producing device.

27. The method of claim 26 wherein said real-time images produced by the IR-capable/visible light-capable image-producing device are presented to the retina superimposed on visible and infrared real, ambient images received directly by the implants from ambient incident light.

28. The method of claim 27 wherein the images produced by IR-capable/visible light-capable image-producing device are presented to the retina either simultaneously or in rapid succession with real, ambient images received directly by the implants from ambient incident light.

29. The method of claim 28 wherein the patient is provided with a patient input device interfaced with the computer means to allow the patient to modify the IR and visible-light images produced by said externally-worn unit.

30. The method of claim 20 comprising implanting a population of such implants in the subretinal space between the outer and inner retina in the eye such that, randomly, about half of them (i.e. the first subpopulation) will be oriented so that the P sides face light incident to the eye, and about half (i.e. the second subpopulation) will be oriented so that their N sides face incident light to the eye.

31. An implant for creating formed vision in the eye, comprising at least two microphotodiode subunits with one being PiN and the other being NiP, so that each of the two subunits has opposite PiN and NiP orientations whereby when the implant is placed in the eye so as to receive incident light, one of the subunits has a PiN configuration relative to incident light and the other subunit has a NiP configuration relative to incident light.

32. The implant as recited in claim 31 wherein the two subunits are symmetrical and have positive pole electrodes on opposite surfaces of the implant and negative pole electrodes on opposite surfaces of the implant, whereby the implant can function in the same manner regardless of which of the two surfaces faces light incident to the eye.

33. The implant as recited in claim 32 wherein the implant comprises two pairs of said two subunits.

34. The implant as recited in claim 31 wherein the implant is between 1 micron and 1000 microns wide and long, and wherein the thickness of the implant is between about 1 to 500 percent of its width.

35. The implant as recited in claim 31 wherein the implant is between about 10 microns and about 50 microns wide and long, and wherein the thickness of the implant is between about 25 to 50 percent of its width.

36. A method of restoring formed vision to a patient having retinal damage, comprising implanting plural implants into the patient'"'"'s eye adjacent the retina, each implant comprising at least two microphotodiode subunits, each of the two subunits having opposite PiN and NiP orientations whereby when the implant is placed in the eye so as to receive incident light, one of the subunits has a PiN configuration relative to incident light and the other subunit has a NiP configuration relative to incident light.

37. The method of claim 36 wherein the two subunits of each implant are symmetrical and have positive pole electrodes on opposite surfaces of the implant and negative pole electrodes on opposite surfaces of the implant, whereby the implant can function in the same manner regardless of which of the two surfaces faces light incident to the eye.

38. The method of claim 37 wherein each implant comprises plural pairs of said two subunits.

39. The method of claim 38 wherein each implant comprises two pairs of said two subunits.

40. The method of claim 36 wherein each implant is between 1 micron and 1000 microns wide and long, and wherein the thickness of the implant is between about 1 to 500 percent of its width.

41. The method of claim 40 wherein the implant is between 10 and 50 microns wide and long, and wherein the thickness of the implant is between about 25 and 50 percent of its width.

42. The method of claim 40, comprising embedding a plurality of said implants into a biologically compatible sheet, and placing the sheet with the embedded implants in the subretinal space.

43. The method of claim 42 comprising placing the sheet with the embedded implants on the nerve fiber layer surface from the vitreous side.

44. The method of claim 43 wherein the sheet is fabricated from a biologically degradable material.

45. The method of claim 36 comprising implanting said implants on the nerve fiber layer surface.

46. A method of restoring formed vision to a patient having retinal damage, comprising implanting plural implants into the patient'"'"'s eye on the nerve fiber layer, each implant comprising a PiN microphotodiode having a P-electrode and an N-electrode, where the P and the N electrodes each contain a projection such that the at least some of the P and the N electrodes of the plural implants penetrate into each of the sublamina A and B layers of the inner plexiform layer.