Topical delivery of L-arginine to cause tissue warming
First Claim
1. A method of warming tissue comprising delivering a nitric oxide releasing substance selected from a member of the group consisting of L-arginine, L-arginine salts and L-arginine derivatives, to skin comprising the step of topically applying to the skin a vehicle containing an effective amount of the substance, and a concentration of ionic salt sufficient to create an ionic environment which causes the substance to migrate from the vehicle to the skin where the substance is absorbed.
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Abstract
A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as warming cold tissue of the hands and feet. Specifically, this is a preparation which provides local delivery of the amino acid L-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow. In the preferred embodiments, the L-arginine is provided so that it can be topically applied to the cold tissue. The preparation also contains agents which aids in the transfer of L-arginine into the tissue. In the preferred embodiments this agent overcomes the resistance to transfer caused by the high charge density of L-arginine. In the preferred embodiments this means is high ionic strength created by addition of choline chloride, magnesium chloride and sodium chloride. This preparation, when topically applied to cold tissue, warming begins within about 10 to 45 minutes and is sustained for periods as long as about 2 to 18 hours.
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Citations
9 Claims
- 1. A method of warming tissue comprising delivering a nitric oxide releasing substance selected from a member of the group consisting of L-arginine, L-arginine salts and L-arginine derivatives, to skin comprising the step of topically applying to the skin a vehicle containing an effective amount of the substance, and a concentration of ionic salt sufficient to create an ionic environment which causes the substance to migrate from the vehicle to the skin where the substance is absorbed.
Specification