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Topical delivery of L-arginine to cause tissue warming

  • US 5,895,658 A
  • Filed: 09/17/1997
  • Issued: 04/20/1999
  • Est. Priority Date: 09/17/1997
  • Status: Expired due to Term
First Claim
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1. A method of warming tissue comprising delivering a nitric oxide releasing substance selected from a member of the group consisting of L-arginine, L-arginine salts and L-arginine derivatives, to skin comprising the step of topically applying to the skin a vehicle containing an effective amount of the substance, and a concentration of ionic salt sufficient to create an ionic environment which causes the substance to migrate from the vehicle to the skin where the substance is absorbed.

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