Flexible artificial nerve plates

• US 5,897,583 A
• Filed: 03/18/1997
• Issued: 04/27/1999
• Est. Priority Date: 07/13/1994
• Status: Expired due to Fees

• Current Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Original Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Inventors: Stieglitz, Thomas, Meyer, Jorg-Uwe
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US08/765,742
• Time in Patent Office: 770 Days
• Field of Search: 607/50, 607/51, 607/115, 607/116, 607/118
• US Class Current: 607/116
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes

Abstract

A flexible and non-conductive, artificial, implantable nerve plate has an module of about 3000-1000 N/mm² and a thickness of <50 μm for placement and insertion between the fascicles of a nerve bundle. Multiple electrodes are arranged on the two sides of the nerve plate, which is connected via conducting lines inside the nerve plate to a cable integrated with the nerve plate; and the cable is connectable to a control and signal receiver unit.

Claims

1. An arrangement for electrically contacting nerve bundles and nerve fibers, comprising:

a flexible, non-conductive, implantable nerve plate for insertion between fascicles of a nerve bundle, said nerve plate have an E-module in a range of from 1,000 to 3,000 N/mm² and a thickness of less than 50 μ

m;

a plurality of electrodes arranged on opposite sides of said nerve plate; and

a plurality of conducting lines arranged inside said nerve plate and connecting said electrodes to a cable which is integrated with said nerve plate, said cable being connectable to a control and signal receiver unit.

2. Arrangement according to claim 1 wherein said nerve plate comprises a polymer material.

3. Arrangement according to claim 2 wherein said polymer material is selected from the group consisting of polyimide and a silicone polymer material.

4. Arrangement according to claim 1 wherein said E-module is in a range of from 2,000 to 2,500 N/mm².

5. Arrangement according to claim 1 wherein said thickness is <

20 μ

m.

6. Arrangement according to claim 1 wherein said thickness is <

10 μ

m.

7. Arrangement according to claim 1 wherein

said electrodes are made of a material selected from the group consisting of platinum, iridium, iridium oxide and gold;

and

said electrodes are connected to one of said control unit for stimulation of the nerves and said signal receiver unit for reception of electroneurograms.

8. Arrangement according to claim 7, wherein transmitter and receiver electrodes are disposed separately on said opposite sides or mixed on both of said opposite sides.

9. Arrangement according to claim 1, wherein said control and signal receiver unit is designed in such a manner that said electrodes can be intermittently impinged with signals for stimulation of the nerves and can receive electroneurograms.

10. Arrangement according to claim 9, wherein times for reception and transmission are of different length, said reception time being 2-100 times longer than the transmission times.

11. Arrangement according to claim 1, wherein 20-300 electrodes are provided on each side of the nerve plate, disposed in rows and columns, and can be controlled in a transmitting mode separately in any combination or can be switched to reception.

12. Arrangement according to claim 1, wherein said cable is designed as a flat strip cable, and is integrated in multiple layers with the nerve plate.

13. Arrangement according to claim 1, wherein said control and signal receiver unit has at least one of preamplifiers and amplifiers and devices of hybrid construction on or at said flat strip cable, for inductive coupling for said transmitter respectively said receiver outside the body.

14. A process for fabricating the flexible, artificial nerve plate of claim 13 for placement or insertion between the fascicles of a nerve bundle having multiple electrodes on one or both sides of said nerve plate having conducting lines inside said nerve plate, and an integrated cable, wherein said nerve plate is fabricated using multilayer technology.

15. A process according to claim 14, wherein said process comprises the steps of:

applying a polymer material by one of spinning, sputtering and spraying on a carrier;

hardening said polymer material by heating;

applying said electrodes and said conducting lines connected thereto inside said nerve plates and said cable, using thin film technology;

applying a second polymer layer;

hardening said second polymer layer;

removing said polymer layer on the electrodes; and

removing the multilayer on said carrier.

16. A process according to claim 15, wherein multiple nerve plates having integrated cables are fabricated in various forms of construction on one silicon wafer.

17. A process according to claim 15, wherein said polymer layers are structured by means of dry etching processes, e.g., reactive ion etching, and, in particular, the electrodes being exposed, and if need be, multiple nerve plates being separated by means of said process.

18. A process according to claim 15, wherein two metal layers having a layer composed of said polymer material lying therebetween are fabricated in such a manner that said nerve plate comprises five layers.