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Antigen-processing cell-targeted conjugates

  • US 5,898,033 A
  • Filed: 12/19/1997
  • Issued: 04/27/1999
  • Est. Priority Date: 06/07/1995
  • Status: Expired due to Term
First Claim
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1. An anti-inflammatory, non-immunogenic conjugate comprising:

  • a polyamino acid backbone;

    a multiplicity of molecules of a non-steroidal anti-inflammatory agent; and

    a multiplicity of moieties linking said molecules to said backbone, wherein said polyamino acid backbone has an average molecular weight greater than 250 kD, said polyamino acid backbone comprises greater than 80 percent poly-γ

    -glutamic acid, said moieties link said molecules of anti-inflammatory agent to said backbone via α

    -carboxylate groups of the poly-γ

    -glutamic acid, and said conjugate is preferentially internalized by antigen-processing cells compared to said agent absent the backbone.

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