Formulations of magnesium compounds for local application and methods of treatment using the same
First Claim
1. A method for treating periodontal disease, which comprises the steps of administering to the oral cavity of a patient in need of such treatment a composition in the form of a dentifrice comprising a pharmaceutically acceptable aqueous-based vehicle and an effective amount of magnesium sulfate heptahydrate, wherein said vehicle is a pharmaceutically acceptable oral carrier, and wherein said magnesium compound is present in said composition an amount effective to provide a hypertonic concentration of the magnesium compound therein, said amount being from about 15% to about 50% by weight of the dentifrice composition.
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Abstract
This invention provides novel pharmaceutical compositions which comprise magnesium compounds in hypertonic amounts. These compositions are formulated for local application for the treatment of conditions such as acne, arthritis, periodontal disease ophthalmic conditions (e.g., conjunctivitis), hemorrhoids, vaginal infections and inflammation, and ulcerative colitis. The compositions are formulated with an acceptable dermatological, oral, rectal, vaginal, or ophthalmic carrier for use in treating these conditions. Also provided is a method for treating asthma wherein the magnesium compositions are administered by inhalation. Any of these treatments, and especially that for asthma, can be supplemented with oral administration of magnesium.
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Citations
12 Claims
- 1. A method for treating periodontal disease, which comprises the steps of administering to the oral cavity of a patient in need of such treatment a composition in the form of a dentifrice comprising a pharmaceutically acceptable aqueous-based vehicle and an effective amount of magnesium sulfate heptahydrate, wherein said vehicle is a pharmaceutically acceptable oral carrier, and wherein said magnesium compound is present in said composition an amount effective to provide a hypertonic concentration of the magnesium compound therein, said amount being from about 15% to about 50% by weight of the dentifrice composition.
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9. A method of treating periodontal disease, which comprises the step of administering to the oral cavity of a patient a composition in the form of a mouthwash comprising a pharmaceutically acceptable aqueous-based vehicle and an effective amount of at least one magnesium compound highly soluble in said vehicle, wherein said vehicle is a pharmaceutically acceptable oral carrier, and wherein said magnesium compound is present in said composition an amount effective to provide a hypertonic concentration of the magnesium compound therein, said amount being from about 25% to about 50% by weight of the mouthwash composition.
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10. A method of treating periodontal disease, which comprises the steps of:
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(i) administering to the oral cavity of a patient a composition in the form of a mouthwash, said composition comprising a pharmaceutically acceptable aqueous-based vehicle and an effective amount of magnesium sulfate heptahydrate, wherein said vehicle is a pharmaceutically acceptable oral carrier, and wherein said magnesium compound is present in said composition an amount effective to provide a hypertonic concentration of the magnesium compound therein, said amount being from about 25% to about 50% by weight of the mouthwash composition; and (ii) applying said composition to the patient'"'"'s gums using vibrational application having a frequency of about 50-100 Hz. - View Dependent Claims (12)
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11. A method of treating periodontal disease, which comprises the step of administering to the oral cavity of a patient a composition in the form of a mouthwash comprising a pharmaceutically acceptable aqueous-based vehicle and an effective amount of magnesium sulfate heptahydrate, wherein said vehicle is a pharmaceutically acceptable oral carrier, and wherein said magnesium compound is present in said composition an amount effective to provide a hypertonic concentration of the magnesium compound therein, said amount being from about 25% to about 50% by weight of the mouthwash composition, and wherein said composition further comprises a cosmetically acceptable foaming agent.
Specification