System for inducing tachycardia utilizing near field T-wave sensing

• US 5,899,929 A
• Filed: 01/27/1998
• Issued: 05/04/1999
• Est. Priority Date: 01/27/1998
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc), Vitatron Medical BV
• Original Assignee: Vitutsom Medical BU
• Inventors: Thompson, David, Westendorp, Hendrikus A., Begemann, Malcolm J.S.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/014,178
• Time in Patent Office: 462 Days
• Field of Search: 607/4, 607/5, 607/9, 607/25, 607/28
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371
• CPC Class Codes: A61N 1/385 Devices for inducing an abnormal cardiac function, e.g. fibrillation

Abstract

A system and method are provided for inducing ventricular tachycardia in a patient to enable testing to determine the optimum parameters for anti-tachycardia stimulation. The implantable device provides for overdrive pacing of the heart for a short sequence, followed by delivery of a series of pulse pairs. Each pulse pair has a first stimulus pulse delivered at the same or similar overdrive rate, and an inducing pulse which is delivered in timed relation to the evoked T-wave, preferably during the falling edge portion of the T-wave. In this way, each cycle the inducing pulse is timed for efficaciously inducing tachycardia. The timing of the inducing pulse is enhanced by near field sensing of the T-wave at about the location where the pulses are delivered, preferably using bipolar sensing and/or sense circuitry designed to recover the signal with an optimum time response. In one preferred embodiment, near field sensing is enabled by use of an FDC circuit. In another preferred embodiment, near field sensing is provided by a pacing lead having bipolar electrodes where the ring electrode is spaced less than 1 mm proximal to the tip electrode.

Claims

1. An implantable pacing system, comprising:

a pacing pulse generator for generating pacing pulses;

a lead with at least one electrode for delivery of pacing pulses at a location of a predetermined one of the patient'"'"'s heart chambers, said lead having a conductor for conducting said pacing pulses from said generator to said electrode;

near field means electrically connected to said electrode for sensing repolarization waves from near said location and for determining the timing of a predetermined portion of each said repolarization wave; and

control means for controlling the timing of generation of pacing pulses by said generator, said control means having series means for controlling generation of a first series of pacing pulses for evoking heartbeats, and inducing means for controlling generation of an inducing pacing pulse as a function of the timing of each said repolarization portion evoked by a pacing pulse of said first series.

2. The system as described in claim 1, wherein said heart chamber is a ventricle, and said near field means has means for sensing T waves and for determining the timing of a predetermined portion of each sensed T wave.

3. The system as described in claim 2, wherein said inducing means comprises increment means for controlling the timing of generation of a next inducing pace pulse after a predetermined time increment following the time of a said T wave portion.

4. The system as described in claim 1, wherein said near field means comprises an FDC circuit with an input connected to said at least one electrode, and said lead is a unipolar lead and said one electrode is a tip electrode.

5. The system as described in claim 1, wherein said lead is a bipolar lead and said at least one electrode is a tip electrode, said lead having a ring electrode proximal to said tip electrode, the spacing between said tip and ring electrodes being less than about 0.75 mm.

6. The system as described in claim 5, wherein said tip electrode has a surface area of 2-6 square mm, and said ring electrode has a surface area greater than 10 square mm.

7. A system for inducing an abnormally high rate in a patient'"'"'s ventricle, comprising:

pacing pulse means for generating a series of pacing pulses at about a predetermined rate;

lead means for delivering said pacing pulses to a location of said ventricle;

near field means for obtaining near field T wave signals from near said location, and determining means for determining a falling edge portion of each said near field T wave signal; and

inducing means for triggering said pacing pulse means to generate an inducing pulse following each said determined falling edge portion, said inducing means comprising timing means for timing an inducing pulse in a predetermined time relation to each said near field T wave signal, whereby a series of inducing pulses are delivered to said patient'"'"'s ventricle.

8. The system as described in claim 7, comprising rate means for controlling said pacing pulse generator to deliver said series of pacing pulses at a rate greater than said patient'"'"'s spontaneous rate.

9. The system as described in claim 7, wherein said lead means comprises a tip electrode, an indifferent electrode located at a distance from said tip electrode, and an FDC circuit is connected in a unipolar mode to receive sensed signals between said tip electrode and said indifferent electrode.

10. The system as described in claim 7, comprising series means for ontrolling said pacing pulse generator to deliver a series of 1-5 pacing pulses and respective inducing pulses.

11. The system as described in claim 10, comprising energy control means for controlling said pacing pulse generator to generate said inducing pulses with an energy level no greater than about twice the patient pacing threshold.

12. The system as described in claim 7, wherein said inducing means comprises means for generating each said inducing pulse immediately upon determining said T wave falling edge portion.

13. The system as described in claim 7, wherein said inducing means comprises means for generating each said inducing pulse after a predetermined time delay following a determined T wave falling edge portion.

14. A system for inducing an abnormally high rate in a patient'"'"'s ventricle, comprising:

pacing pulse means for generating a series of pacing pulses at about a predetermined rate;

lead means for delivering said pacing pulses to a location of said ventricle and for sensing cardiac signals, said lead means having a tip electrode for positioning at about said location and a ring electrode spaced proximally from said tip electrode by an inter-electrode distance of less than about 1 mm, whereby near field T wave signals are obtained between said electrodes; and

inducing means for triggering said pacing pulse means to generate an inducing pulse following each said obtained near field T wave signal, said inducing means comprising timing means for timing an inducing pulse in a predetermined time relation to each said near field T wave signal, whereby a series of inducing pulses are delivered to said patient'"'"'s ventricle.

15. The system as described in claim 14, comprising rate means for controlling said pacing pulse generator to deliver said series of pacing pulses at a rate greater than said patient'"'"'s spontaneous rate.

16. The system as described in claim 14, wherein said tip electrode has a surface area of no more than about 6-8 square mm, and said ring electrode has a surface area of greater than 20 square mm.

17. The system as described in claim 14, comprising series means for controlling said pacing pulse generator to deliver a series of 1-5 pacing pulses and respective inducing pulses.

18. The system as described in claim 17, comprising energy control means for controlling said pacing pulse generator to generate said inducing pulses with an energy level no greater than about twice the patient pacing threshold.

19. The system as described in claim 14, wherein said inducing means comprises means for generating each said inducing pulse immediately upon obtaining said near field T wave signal.

20. The system as described in claim 14, wherein said near field means comprises means for determining the time of occurrence of a predetermined portion of a said near field T wave signal, and wherein said inducing means comprises means for generating each said inducing pulse after a predetermined time delay following said occurrence.

21. The system as described in claim 14, wherein said inter-electrode distance is less than about 0.75 mm.