Differential conductivity hemodynamic monitor

• US 5,900,726 A
• Filed: 06/16/1997
• Issued: 05/04/1999
• Est. Priority Date: 09/30/1992
• Status: Expired due to Fees

• Current Assignee: Gambro Renal Products, Inc. (Baxter International Inc.)
• Original Assignee: COBE Laboratories Incorporated (Terumo Corporation)
• Inventors: Brugger, James M., Buffaloe, George W. IV, Ogawa, Francis T.
• Primary Examiner(s): BROWN, GLENN WARNER
• Application Number:
  US08/876,445
• Time in Patent Office: 687 Days
• Field of Search: 324/425, 324/439, 324/692, 324/705, 324/71.1, 210/96.1, 210/646, 436/150, 604/30, 604/65, 604/246, 73/861.07, 73/861.08
• US Class Current: 324/71.1
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3655 Arterio-venous shunts or fistulae
• CPC Class Codes: A61M 1/3658 Indicating the amount of purified blood recirculating in the fistula or shunt
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 1/3661 for haemodialysis
• CPC Class Codes: A61M 1/3669 Electrical impedance measurement of body fluids; transducers specially adapted therefor
• CPC Class Codes: G01F 1/7046 using electrical loaded particles as tracer, e.g. ions or electrons
• CPC Class Codes: G01F 1/708 Measuring the time taken to traverse a fixed distance
• CPC Class Codes: G01F 1/7088 using electrically charged particles as tracers

Abstract

A flow rate of a fluid flowing in a tube is quantitatively determined by altering the electrical conductivity of the fluid by injection of a bolus of saline. The electrical conductivity of the altered conductivity is measured over the time it takes the altered conductivity fluid to pass a conductivity measuring location. The measured conductivity is integrated over the time it takes to pass the conductivity measuring location. The integral is interpreted to determine the flow rate.

Claims

1. An apparatus for quantitatively determining a fluid flow parameter of blood having a physical property flowing in an arterio-venous fistula into which first blood having a first initial value of said physical property is being inserted and from which second blood having a second initial value of said physical property is simultaneously being withdrawn, comprising:

means for altering the value of the physical property of the first blood;

means for measuring the value of the physical property of the first blood after the value of the physical property is altered and before the first blood is inserted into the arterio-venous fistula;

means for measuring the value of the physical property of the second blood after it is withdrawn from the arterio-venous fistula; and

means for comparing the measured altered value of the physical property of the first blood with the measured value of the physical property of the second blood to quantitatively determine the fluid flow parameter of blood flowing in the arterio-venous fistula.

2. An apparatus as defined in claim 1 wherein:

the means for altering the value of the physical property of the first blood further comprises;

means for injecting a marker fluid having a value of the physical property different than the first initial value of the physical property.

3. An apparatus as defined in claims 1 or 2 wherein the physical property is electrical conductivity.

4. An apparatus as defined in claim 1 wherein the first blood is treated blood being delivered from a hemodialysis apparatus.

5. An apparatus as defined in claim 1 wherein the second blood is untreated blood being delivered to a hemodialysis apparatus.

6. An apparatus as defined in claim 1 wherein the fluid flow parameter is a degree of recirculation flow.

7. A method for quantitatively determining a fluid flow parameter of blood having a physical property flowing in an arterio-venous fistula into which first blood having a first initial value of said physical property is being inserted and from which second blood having a second initial value of said physical property is simultaneously being withdrawn, comprising:

altering the value of the physical property of the first blood;

measuring the value of the physical property of the first blood after the value of the physical property is altered and before the first blood is inserted into the arterio-venous fistula;

measuring the value of the physical property of the second blood after it is withdrawn from the arterio-venous fistula; and

comparing the measured altered value of the physical property of the first blood with the measured value of the physical property of the second blood to quantitatively determine the fluid flow parameter of the blood flowing in the arterio-venous fistula.

8. A method as defined in claim 7 wherein:

the step of altering the value of the physical property of the first blood further comprises;

injecting a marker fluid having a value of the physical property different from the value of the physical property of the first blood.

9. A method as defined in claim 7 wherein the physical property is electrical conductivity.

10. A method as defined in claim 7 wherein the first blood is treated blood being delivered from a hemodialysis apparatus.

11. A method as defined in claim 7 wherein the second blood is untreated blood being delivered to a hemodialysis apparatus.

12. A method as defined in claim 7 wherein the fluid flow parameter is a degree of recirculation flow.