Transcervical intrauterine applicator for intrauterine hyperthermia

• US 5,902,251 A
• Filed: 05/05/1997
• Issued: 05/11/1999
• Est. Priority Date: 05/06/1996
• Status: Expired due to Fees

• Current Assignee: Neil C. Vanhooydonk
• Original Assignee: Neil C. Vanhooydonk
• Inventors: vanHooydonk, Neil C.
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): Wingood, Pamela L.
• Application Number:
  US08/851,099
• Time in Patent Office: 736 Days
• Field of Search: 600/549, 606/33, 606/28, 128/1, 128/2, 128/3
• US Class Current: 600/549
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2017/00544 pneumatically
• CPC Class Codes: A61B 2017/4216 Operations on uterus, e.g. endometrium
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00214 Expandable means emitting energy, e.g. by elements carried thereon
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00559 Female reproductive organs
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00738 Depth, e.g. depth of ablation
• CPC Class Codes: A61B 2018/00797 measured by multiple temperature sensors
• CPC Class Codes: A61B 2018/00821 measured by a thermocouple
• CPC Class Codes: A61B 2018/1435 Spiral
• CPC Class Codes: A61B 2018/1861 with an instrument inserted into a body lumen or cavity, e.g. a catheter
• CPC Class Codes: A61N 5/045 specially adapted for treatment inside the body

Abstract

A transcervical intrauterine catheter applicator for the hyperthermia/thermal therapy treatment of the uterus. The applicator includes one or more EMR antennas and one or more temperature sensors for measuring the temperature of the endometrial tissue. Each EMR antenna has an elongated helical coil connected to the center conductor of a coaxial cable to thereby generate a light bulb shaped radiation pattern and thus generate a similar-shaped pattern of thermal energy in the endometrium tissue. The catheter can be of the balloon type that can be inflated, thereby radially moving the antenna and temperature sensor against the walls of the uterus.

Claims

1. A method for thermally treating tissue of a body cavity having an entrance opening and a closed end, and that is irregular shaped when collapsed, comprising the steps of:

inserting a catheter portion of an applicator having an antenna into the entrance opening of the collapsed body cavity;

expanding in the collapsed body cavity a noncompliant angioplasty type balloon to a fixed shape that is different from that of the collapsed body cavity to conform the shape of the body cavity to said fixed shape;

applying electromagnetic energy to the antenna at a power level and for a time interval sufficient to cause ablation of the tissue of the body cavity including the closed end thereof; and

producing a transmitted electromagnetic radiation pattern by said antenna, said radiation pattern having a shape generally the same as the fixed shape of the expanded angioplasty type balloon.

2. The method of claim 1 further including conforming a uterine cavity to a pear shape with said angioplasty type balloon, and ablating a desired thickness of the endometrium tissue.

3. The method of claim 1, further including expanding a portion of the applicator so as to force the tissue of the body cavity to conform to said fixed shape.

4. The method of claim 3, further including compressing the body tissue and reducing blood flow therein, thereby reducing thermal dissipation caused by the flow of blood in said tissue.

5. The method of claim 1, further including expanding said balloon catheter so as to change the irregular shape of the collapsed body cavity to a predefined shape defined by said fixed shape.

6. The method of claim 1, further including a plurality of antennas, and positionally inserting said antennas into respective lumens of the catheter portion of the applicator to achieve a desired radiation pattern.

7. The method of claim 1, further including thermally treating body tissues of non-uniform thickness by simultaneously causing a higher density of energy to be induced into the thicker tissue and a lower density of energy to be induced into the thinner tissue.

8. The method of claim 1, further including using an applicator having a spiral antenna curved over a tip thereof so as to provide radiation axially from the tip of said antenna.

22. The method of claim 1, further including expanding the angioplasty type balloon to the fixed shape to thereby open cornus portions of a uterus against an outer surface of said balloon.

9. A method for ablating endometrial tissue of a uterine cavity, comprising the steps of:

inserting a balloon catheter having at least one antenna therein into the uterine cavity; and

applying electrical energy to said antenna so as to produce an electromagnetic radiation for treating the endometrial tissue of the uterine cavity, said antenna being configured so that said radiation pattern is generally an inverted pear shape.

10. The method of claim 9, further including expanding an angioplasty type of balloon catheter to enlarge the uterine cavity and move the cornus portions thereof toward each other and closer to said antenna.

11. The method of claim 10, further including moving the cornus portions so that the isotherms more uniformly heat the cornus portions of the uterus.

12. The method of claim 9, further including conforming the physical shape of the antenna to at least a portion of said pear shape.

20. The method of claim 9, further including treating non-uniform thicknesses of uterine cavity tissue by offsetting an axial axis of the antenna with respect to an axis of the balloon.

13. An applicator for generating electromagnetic energy and insertable into a body cavity for treatment of body tissues, comprising:

a catheter having a portion thereof that is expandable when pressure is applied thereto, a body portion of said catheter having at least one lumen constructed therein, said lumen extending into said expandable portion of the catheter; and

an antenna supported by the catheter lumen, whereby when said catheter portion is expanded, the tissue of the body cavity and the expandable portion of the catheter are forced to conforming shapes, and the physical shape of the antenna conforms to the shape of the body tissue in contact with the expandable portion of the catheter.

14. The applicator of claim 13, wherein said catheter includes a cavity that can be filled with a fluid so that a pressure thereof causes an expansion of the expandable portion.

15. The applicator of claim 13, wherein the expandable portion of said catheter expands to a predefined shape that is independent of the shape of the body cavity.

16. The applicator of claim 13, further including a plurality of antennas insertable within respective lumens formed in said catheter body.

17. The applicator of claim 13, further including means for circulating a cooling liquid through said applicator.

18. The applicator of claim 13, further including means for mechanically expanding a balloon portion of said catheter.

19. The applicator of claim 13, wherein said antenna comprises a helical coil formed in a curve around a distal tip of said catheter expandable portion.

21. An applicator for generating electromagnetic energy and insertable into a body cavity for treatment of body tissues, comprising:

a catheter having a portion thereof that is expandable to a shaped envelope when pressure is applied thereto, a body portion of said catheter having at least one lumen constructed therein; and

an elongate antenna structure supported by the catheter lumen, and being insertable into the catheter lumen so as to be disposed centrally within said envelope when expanded, said antenna producing a radiation pattern generally the same shape as a sidewall and end surface of said envelope when expanded.