Apparatus for analyzing body fluids

• US 5,902,253 A
• Filed: 06/11/1997
• Issued: 05/11/1999
• Est. Priority Date: 06/11/1996
• Status: Expired due to Term

• Current Assignee: Sphere Medical Limited (Sphere Medical Holding Ltd.)
• Original Assignee: Siemens-Elema AB (Siemens AG)
• Inventors: Von Bahr, Pontus, Pfeiffer, Georg
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): MARMOR II, CHARLES ALAN
• Application Number:
  US08/873,109
• Time in Patent Office: 699 Days
• Field of Search: 600/573, 600/575, 600/578, 600/584, 600/581, 600/582
• US Class Current: 600/584
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 2010/0003 including means for analysis by an unskilled person
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence

Abstract

An arrangement for analyzing body fluids drawn from a living subject has a fluid sample station connectable to the subject for drawing fluid from the subject, a disposable cassette connectable to the fluid sample station for receiving a fluid sample to be analyzed, a sensor unit for analyzing the fluid sample, a cassette store in which a plurality of disposable cassettes are storable and a transfer system for bringing cassettes in the cassette store, one by one, into operative connection with the fluid sample station. A control unit controls the transfer system to bring the respective cassettes into connection with the fluid sample station at a programmable rate.

Claims

1. An apparatus for analyzing body fluids from a living subject comprising:

fluid sampling means continuously in fluid communication with to a living subject for drawing a fluid therefrom for the duration of a fluid sampling procedure;

sensor means for analyzing said fluid;

a cassette magazine containing a plurality of disposable cassettes;

transfer means for successively bringing cassettes individually from said cassette magazine into and out of fluid communication with said fluid sampling means for allowing said fluid to flow into a cassette while in fluid communication with said fluid sampling means for analysis of the fluid in the cassette by said sensor means; and

control means for controlling said transfer means to successively bring said cassettes individually into and out of fluid communication with said fluid sampling means at a programmable rate.

2. An apparatus as claimed in claim 1 wherein said sensor means comprises a plurality of individual sensor units respectively contained in said plurality of disposable cassettes, and each cassette further comprising interface means for exchanging signals between the sensor unit in that cassette and said control means while that cassette is in fluid communication with said fluid sampling means.

3. An apparatus as claimed in claim 2 further comprising means for filling each cassette, while in fluid communication with said fluid sampling means, with a calibration solution for the sensor unit contained in that cassette.

4. An apparatus as claimed in claim 2 wherein each disposable cassette contains a cartridge containing calibration solution for the sensor unit contained in that cassette.

5. An apparatus as claimed in claim 2 wherein said fluid sampling means comprises a supply of calibration solution for said sensor means.

6. An apparatus as claimed in claim 5 wherein said control means comprises means for releasing said calibration solution to said sensor means for calibrating said sensor means.

7. An apparatus as claimed in claim 1 wherein said sensor means comprises a plurality of sensor elements respectively contained in said plurality of disposable cassettes, a single analyzing unit, and a plurality of interface means respectively contained in said plurality of disposable cassettes for providing a communication interface between the sensor element in a cassette and said control means while fluid is flowing in that cassette.

8. An apparatus as claimed in claim 1 further comprising a measurement station at which said sensor means are disposed, wherein said transfer means comprises means for successively bringing said cassettes individually into and out of connection with said measurement station, and wherein said control means comprises means for controlling said transfer means for bringing each cassette into connection with said measurement station after that cassette has been filled with an amount of said fluid from said fluid sampling means.

9. An apparatus as claimed in claim 8 wherein said transfer means comprises a tube and means for transporting a cassette through said tube from said cassette magazine into fluid communication with said fluid sampling means.

10. An apparatus as claimed in claim 9 wherein said transfer system comprises means for pneumatically transporting said cassette through said tube.

11. An apparatus as claimed in claim 9 wherein said transfer system comprises means for mechanically transporting said cassette through said tube.

12. An apparatus as claimed in claim 9 wherein said transfer system comprises means for electromagnetically transporting said cassette through said tube.

13. An apparatus as claimed in claim 1 wherein each disposable cassette comprises a filling detector for sensing an amount of fluid entered into said cassette.

14. An apparatus as claimed in claim 1 wherein said fluid sampling means comprises means for drawing blood from said subject and wherein said sensor means comprises means for analyzing a blood gas content of blood in a cassette in fluid communication with said fluid sampling means.

15. An apparatus as claimed in claim 1 wherein said sensor means comprises an optical sensor element.

16. An apparatus as claimed in claim 1 wherein said sensor means comprises an electrochemical sensor element.

17. An apparatus as claimed in claim 1 wherein said sensor means comprises an optical sensor element and an electrochemical sensor element.

18. An apparatus as claimed in claim 1 wherein said fluid sampling means comprises a sample membrane adapted for connection to said fluid.

19. An apparatus as claimed in claim 1 wherein each cassette comprises a cassette membrane separating an interior of said cassette from an exterior of said cassette.

20. An apparatus as claimed in claim 19 further comprising an interior evacuated volume in said cassette.

21. An apparatus for analyzing body fluids from a living subject comprising:

fluid sampling means continuously in fluid communication with to a living subject for drawing a fluid therefrom for the duration of a fluid sampling procedure;

a cassette in fluid communication with said fluid sampling means through which fluid drawn from said subject flows;

a sensor magazine containing a plurality of disposable sensor elements;

transfer means for successively bringing sensor elements individually from said sensor magazine into and out of communication with said fluid in said cassette for analyzing said fluid in said cassette; and

control means for controlling said transfer means to successively bring said sensor elements individually into and out of communication with said fluid in said cassette at a programmable rate.