Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
First Claim
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1. A drug reservoir for use in a transdermal drug delivery system, comprising a layer of a polyurethane hydrogel having a drug formulation comprising at least one permeation enhancer absorbed therein.
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Abstract
High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate crosslinking agents or cured with radiation in the presence of a photoinitator. Drug loading as high as 65 to 70 wt. % or higher can be achieved by absorbing drug formulation into the reservoir after hydrogel synthesis. Methods for making and using transdermal systems containing such reservoirs are provided as well.
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Citations
27 Claims
- 1. A drug reservoir for use in a transdermal drug delivery system, comprising a layer of a polyurethane hydrogel having a drug formulation comprising at least one permeation enhancer absorbed therein.
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5. A transdermal drug delivery system, comprising a laminated composite of:
- a high capacity drug reservoir of a polyurethane hydrogel having a drug formulation comprising at least one permeation enhancer contained therein; and
a backing layer that is substantially impermeable to the drug and which defines the upper surface of the system during drug delivery. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- a high capacity drug reservoir of a polyurethane hydrogel having a drug formulation comprising at least one permeation enhancer contained therein; and
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17. A method for preparing a transdermal drug delivery system having a high capacity, polyurethane hydrogel drug reservoir, comprising:
- (a) reacting a polyurethane with a crosslinking agent in the presence of water, for a time period effective to form a hydrogel;
(b) absorbing a drug formulation comprising at least one permeation enhancer into the hydrogel to form a drug-containing hydrogel; and
laminating a backing layer to the hydrogel that is substantially impermeable to the drug and serves as the upper surface of the system during drug delivery. - View Dependent Claims (18, 19, 20, 21, 22)
- (a) reacting a polyurethane with a crosslinking agent in the presence of water, for a time period effective to form a hydrogel;
- 25. A drug reservoir for use in a transdermal drug delivery system, comprising a layer of a polyurethane hydrogel having a drug formulation absorbed therein, where the drug formulation comprises an androgenic agent and a permeation enhancer.
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27. A drug reservoir for use in a transdermal drug delivery system comprising a layer of a polyurethane hydrogel having a drug formulation absorbed therein, wherein the drug formulation comprises an androgenic agent and a permeation enhancer.
Specification