×

Cell encapsulation device

  • US 5,902,745 A
  • Filed: 05/21/1997
  • Issued: 05/11/1999
  • Est. Priority Date: 09/22/1995
  • Status: Expired due to Term
First Claim
Patent Images

1. A cell encapsulation device comprising:

  • A cell zone comprising a space delimited by a water wettable cover surrounding a cell displacing core within the cover;

    wherein the cover has a coating thereon, the coating comprising a hydrophilic polymer material cross-linked to itself, wherein the cover is permeable to water and impermeable to cells such that the cover is a means to filter cells from solution upon introduction of cells and solution into the cell zone under a pressure less than about 6.9×

    105 Pa, thereby causing the solution to weep through the cover at a rate ranging from about 0.01 ml/cm2 /minute to about 100 ml/cm2 /minute while retaining the cells within the device;

    wherein the core comprises a swellable material that expands form an initial first radial dimension to an enlarged second radial dimension upon exposure to an aqueous solution;

    at least ne opening within the cover;

    a cell delivery device to transfer cells into the device through the opening; and

    means to seal the opening following introduction of cells into the device.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×