Spiro-Azabicyclic Compounds useful in therapy
First Claim
Patent Images
1. A compound of formula I:
- ##STR9## wherein R represents hydrogen or methyl; and
n represents 1 or 2;
or a pharmaceutically acceptable acid addition salt or enantiomer thereof.
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Abstract
There are provided new compounds of formula I: ##STR1## wherein R represents hydrogen or methyl; and
n represents 1 or 2;
or a pharmaceutically acceptable acid addition salt thereof, together with processes for preparing them, compositions containing them and their use in therapy. Compounds of formula I are expected to be useful in the treatment of psychotic disorders, intellectual impairment disorders and anxiety.
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Citations
14 Claims
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1. A compound of formula I:
- ##STR9## wherein R represents hydrogen or methyl; and
n represents 1 or 2; or a pharmaceutically acceptable acid addition salt or enantiomer thereof. - View Dependent Claims (2, 8, 9, 10, 11, 13)
- ##STR9## wherein R represents hydrogen or methyl; and
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3. Spiro 1-azabicyclo 2.2.2!octane-3,5'"'"'-oxazolidine!-2'"'"'-one, or a pharmaceutically acceptable acid addition salt or enantiomer thereof.
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4. (+)-Spiro 1-azabicyclo 2.2.2!octane-3,5'"'"'-oxazolidine!-2'"'"'-one, or a pharmaceutically acceptable acid addition salt thereof.
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5. (-)-Spiro 1-azabicyclo 2.2.2!octane-3,5'"'"'-oxazolidine!-2'"'"'-one, or a pharmaceutically acceptable acid addition salt thereof.
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6. Spiro 1-azabicyclo 2.2.1!heptan-3,5'"'"'-oxazolidin-2'"'"'-one!, or a pharmaceutically acceptable acid addition salt or enantiomer thereof.
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7. 3'"'"'-Methyl spiro- 1-azabicyclo 2.2.2!octan-3,5'"'"'-oxazolidin-2'"'"'-one!, or a pharmaceutically acceptable acid addition salt or enantiomer thereof.
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12. A compound of formula IV ##STR12## wherein n is 1 or 2, or a salt or enantiomer thereof.
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14. A compound of formula III ##STR13## wherein n is 1 or 2 and R represents methyl, or a salt or enantiomer thereof.
Specification