Method for treating ophthalmic diseases

• US 5,904,144 A
• Filed: 03/22/1996
• Issued: 05/18/1999
• Est. Priority Date: 03/22/1996
• Status: Expired due to Term

• Current Assignee: Neurotech USA, Inc. (Woodbrook Group Holdings, Inc.)
• Original Assignee: Cytotherapeutics, Inc.
• Inventors: Spear, Peter D., Tsiaras, William G., Baetge, E. Edward, Hammang, Joseph P.
• Primary Examiner(s): Yu, Mickey
• Assistant Examiner(s): O'Hara, Kelly
• Application Number:
  US08/620,982
• Time in Patent Office: 1,152 Days
• Field of Search: 604/49, 604/290, 604/289, 604/890.1, 604/891.1, 128/897, 128/898, 424/424, 424/427, 623/4
• US Class Current: 128/898
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 2035/128 capsules, e.g. microcapsules
• CPC Class Codes: A61K 48/005 characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61P 27/00 Drugs for disorders of the senses
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

The present invention provides novel devices and methods for continuous, controlled delivery of a biologically active molecule to the eye, either intraocularly or periocularly, to treat ophthalmic disorders. A capsule is surgically placed in the desired location in the eye. The capsule includes cells which produce the biologically active molecule. The capsule also includes a surrounding biocompatible jacket through which the biologically active molecule may diffuse into the eye. This jacket may immunoisolate the encapsulated cells, protecting them from attack by the immune system of the patient.

Claims

1. A method for delivering a biologically active molecule to the eye comprising:

implanting a capsule periocularly, the capsule comprising a core containing living cells providing a cellular source of the biologically active molecule and a surrounding biocompatible jacket, the jacket permitting diffusion of the biologically active molecule into the eye.

2. The method of claim 1 wherein the jacket comprises a permselective, immunoisolatory membrane.

3. The method of claim 1 wherein the capsule is implanted in the sub-Tenon'"'"'s space.

4. The method of claim 1 wherein the capsule is configured as a hollow fiber or a flat sheet.

5. The method of claim 1 wherein the biologically active molecule is selected from the group consisting of neurotrophic factors, anti-angiogenic factors, growth factors, antibodies and antibody fragments, neurotransmitters, hormones, enzymes, cytokines and lymphokines.

6. The method of claim 1 wherein a second biologically active molecule is co-delivered from the capsule to the eye.

7. A method for delivery of biologically active molecules to an eye comprising:

implanting a first capsule intraocularly, the capsule comprising a core containing living cells providing a cellular source of a first biologically active molecule and a surrounding biocompatible jacket, the jacket permitting diffusion of the biologically active molecule into the eye;

implanting a second capsule periocularly, the capsule comprising a core containing living cells providing a cellular source of a second biologically active molecule and a surrounding biocompatible jacket, the jacket permitting diffusion of the biologically active molecule into the eye.

8. The method of claim 7 wherein the first capsule is implanted in the posterior chamber and the second capsule is implanted in the sub-Tenon'"'"'s space.

9. A method for delivering a biologically active molecule to the eye comprising:

implanting a capsule into the posterior chamber of the eye, the capsule comprising a core containing living cells providing a cellular source of the biologically active molecule and a surrounding biocompatible jacket, the jacket permitting diffusion of the biologically active molecule into the eye;

the capsule configured in a shape adapted to implantation in the posterior chamber and having a tether adapted for anchoring the capsule to an ocular structure.

10. The method of claim 9 wherein the jacket comprises a permselective, immunoisolatory membrane.

11. The method of claim 9 wherein the jacket comprises a microporous membrane.

12. The method of claim 9 wherein the biologically active molecule is selected from the group consisting of neurotrophic factors, anti-angiogenic factors, growth factors, antibodies and antibody fragments, neurotransmitters, hormones, enzymes, cytokines and lymphokines.

13. The method of claim 9 wherein a second biologically active molecule is co-delivered from the capsule to the eye.