Method and device for reconstruction of articular cartilage
First Claim
1. Method for promoting the repair of a lesion extending through articular cartilege into bone comprising the steps of:
- providing a biodegradable carrier carrying a chemotactic ground substance, with the biodegradable carrier being formed by a structure having surfaces, with the chemotactic ground substance being carried by the surfaces and separate from the structure, wherein the providing step comprises the step of providing the biodegradable carrier including at least one biological modifier incorporated in the biodegradable carrier selected from the group of;
modifiers being joined to the surfaces of the structure, modifiers being joined to the chemotactic ground substance, modifiers being located between the structure and the chemotactic ground substance, and modifiers being carried within the chemotactic ground substance;
harvesting precursor cells for the production of connective tissue;
securing the precursor cells to the biodegradable carrier;
shaping the biodegradable carrier and the precursor cells secured thereto to the shape of the lesion, with the shaped biodegradable carrier and the precursor cells secured thereto having a peripheral surface; and
implanting the biodegradable carrier and the precursor cells secured thereto into the lesion with the peripheral surface of the biodegradable carrier and the precursor cells abutting with the lesion.
2 Assignments
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Accused Products
Abstract
A biodegradable device for facilitating healing of structural voids in bone, cartilage as well as soft tissue is disclosed in the most preferred form including a porous macrostructure made from a biodegradable polymer and a chemotactic ground substance in the form of an RGD attachment moiety of fibronectin formed as a porous microstructure. For repair of articular cartilage, harvested precursor cells are secured to the biodegradable carrier which is shaped for press fitting into the articular cartilage lesion. In the most preferred form, the chemotactic ground substance enhances the attractiveness of the biodegradable device for cellular attachment at the site of repair and also facilitates the attachment of free, precursor cells such as chondrocytes and bone marrow to the biodegradable device. In the most preferred form, biological modifiers such as transforming growth factor B and basic fibroblastic growth factor is incorporated in the biodegradable device to mediate cellular activity and regulate cellular functions.
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Citations
25 Claims
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1. Method for promoting the repair of a lesion extending through articular cartilege into bone comprising the steps of:
- providing a biodegradable carrier carrying a chemotactic ground substance, with the biodegradable carrier being formed by a structure having surfaces, with the chemotactic ground substance being carried by the surfaces and separate from the structure, wherein the providing step comprises the step of providing the biodegradable carrier including at least one biological modifier incorporated in the biodegradable carrier selected from the group of;
modifiers being joined to the surfaces of the structure, modifiers being joined to the chemotactic ground substance, modifiers being located between the structure and the chemotactic ground substance, and modifiers being carried within the chemotactic ground substance;
harvesting precursor cells for the production of connective tissue;
securing the precursor cells to the biodegradable carrier;
shaping the biodegradable carrier and the precursor cells secured thereto to the shape of the lesion, with the shaped biodegradable carrier and the precursor cells secured thereto having a peripheral surface; and
implanting the biodegradable carrier and the precursor cells secured thereto into the lesion with the peripheral surface of the biodegradable carrier and the precursor cells abutting with the lesion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
- providing a biodegradable carrier carrying a chemotactic ground substance, with the biodegradable carrier being formed by a structure having surfaces, with the chemotactic ground substance being carried by the surfaces and separate from the structure, wherein the providing step comprises the step of providing the biodegradable carrier including at least one biological modifier incorporated in the biodegradable carrier selected from the group of;
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11. Method for promoting the repair of a lesion extending through articular cartilage into bone comprising the steps of:
- providing a biodegradable carrier formed from a porous, biodegradable polymer having surfaces and carrying a chemotactic ground substance in turn carrying an RGD attachment moiety of fibronectin, with the chemotactic ground substance being carried by the surfaces and separate from the structure, wherein the providing step comprises the step of providing the biodegradable carrier including at least one biological modifier incorporated in the biodegradable carrier selected from the group of;
modifiers being joined to the surfaces of the structure, modifiers being joined to the chemotactic ground substance, modifiers being located between the structure and the chemotactic ground substance, and modifiers being carried within the chemotactic ground substance;
harvesting precursor cells for the production of connective tissue;
securing the precursor cells to the biodegradable carrier;
shaping the biodegradable carrier and the precursor cells secured thereto to the shape of the lesion, with the shaped biodegradable carrier and the precursor cells secured thereto having a peripheral surface; and
press fitting the biodegradable carrier and the precursor cells secured thereto into the lesion with the peripheral surface of the biodegradable carrier and the precursor cells abutting with the lesion. - View Dependent Claims (12)
- providing a biodegradable carrier formed from a porous, biodegradable polymer having surfaces and carrying a chemotactic ground substance in turn carrying an RGD attachment moiety of fibronectin, with the chemotactic ground substance being carried by the surfaces and separate from the structure, wherein the providing step comprises the step of providing the biodegradable carrier including at least one biological modifier incorporated in the biodegradable carrier selected from the group of;
Specification