Imaging system and method using direct reconstruction of scattered radiation

• US 5,905,261 A
• Filed: 09/25/1997
• Issued: 05/18/1999
• Est. Priority Date: 12/01/1995
• Status: Expired due to Term

• Current Assignee: Perkinelmer Health Sciences Incorporated (Perkinelmer Incorporated)
• Original Assignee: John T. Peoples
• Inventors: Ishii, Masaru, Schotland, John Carl
• Primary Examiner(s): Westin, Edward P.
• Assistant Examiner(s): HANIG, RICHARD E
• Application Number:
  US08/937,715
• Time in Patent Office: 600 Days
• Field of Search: 250/358.1, 250/330, 128/665, 128/663, 128/664
• US Class Current: 250/341.8
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

A method for the direct, mathematical reconstruction of the image of an object from measurements of the transmitted intensity of the scattered radiation effected by irradiating the object. The transmitted coefficient is related to the image by an integral operator. The image is directly, mathematical reconstructed by executing a prescribed mathematical algorithm, as determined with reference to the integral operator, on the transmitted coefficient, the algorithm further relating the absorption coefficient, the diffusion coefficient, or both to the transmitted coefficient by a different integral operator.

Claims

1. A method for generating an absorption image of an object comprising the steps of

irradiating the object with a source of radiation,

measuring a transmission coefficient due predominantly to diffusively scattered radiation wherein said transmission coefficient is related to the absorption coefficient by an integral operator, and

directly reconstructing the image by executing a prescribed mathematical algorithm, determined with reference to said integral operator, on said transmission coefficient, said algorithm further relating the absorption coefficient to said transmission coefficient by another integral operator.

2. The method as recited in claim 1 wherein the step of directly reconstructing includes the step of iteratively reconstructing the image.

3. Circuitry for generating an absorption image of an object comprising

irradiation means for irradiating the object with a source of radiation,

measurement means, responsive to the means for irradiating, for measuring a transmission coefficient due predominantly to diffusively scattered radiation wherein said transmission coefficient is related to the absorption coefficient by an integral operator, and

reconstruction means, responsive to the means for measuring, for directly reconstructing the image by executing a prescribed mathematical algorithm, determined with reference to said integral operator, on said transmission coefficient, said algorithm further relating the absorption coefficient to said transmission coefficient by another integral operator.

4. The circuitry as recited in claim 3 wherein the reconstruction means includes means for iteratively reconstructing the image.

5. A method for generating an diffusion image of an object comprising the steps of

irradiating the object with a source of radiation,

measuring a transmission coefficient due predominantly to diffusively scattered radiation wherein said transmission coefficient is related to the diffusion coefficient by an integral operator, and

directly reconstructing the image by executing a prescribed mathematical algorithm, determined with reference to said integral operator, on said transmission coefficient, said algorithm further relating the diffusion coefficient to said transmission coefficient by another integral operator.

6. The method as recited in claim 5 wherein the step of directly reconstructing includes the step of iteratively reconstructing the image.

7. Circuitry for generating an diffusion image of an object comprising

irradiation means for irradiating the object with a source of radiation,

measurement means, responsive to the means for irradiating, for measuring a transmission coefficient due predominantly to diffusively scattered radiation wherein said transmission coefficient is related to the diffusion coefficient by an integral operator, and

reconstruction means, responsive to the means for measuring, for directly reconstructing the image by executing a prescribed mathematical algorithm, determined with reference to said integral operator, on said transmission coefficient, said algorithm further relating the diffusion coefficient to said transmission coefficient by another integral operator.

8. The circuitry as recited in claim 7 wherein the reconstruction means includes means for iteratively reconstructing the image.

9. A method for generating absorption and diffusion images of an object comprising the steps of

irradiating the object with a source of radiation,

measuring a transmission coefficient due predominantly to diffusively scattered radiation wherein said transmission coefficient is related to the absorption coefficient and diffusion coefficient by an integral operator, and

directly reconstructing the images by executing a prescribed mathematical algorithm, determined with reference to said integral operator, on said transmission coefficient, said algorithm further relating the absorption coefficient and the diffusion coefficient to said transmission coefficient by another integral operator.

10. The method as recited in claim 9 wherein the step of directly reconstructing includes the step of iteratively reconstructing the image.

11. Circuitry for generating absorption and diffusion images comprising

irradiation means for irradiating the object with a source of radiation,

measurement means, responsive to the means for irradiating, for measuring a transmission coefficient due predominantly to diffusively scattered radiation wherein said transmission coefficient is related to the absorption coefficient and the diffusion coefficient by an integral operator, and

reconstruction means, responsive to the means for measuring, for directly reconstructing the images by executing a prescribed mathematical algorithm, determined with reference to said integral operator, on said transmission coefficient, said algorithm further relating the absorption coefficient and the diffusion coefficients to said transmission coefficient by another integral operator.

12. The circuitry as recited in claim 11 wherein the reconstruction means includes means for iteratively reconstructing the image.