Heat treatment of inflamed tissue

• US 5,906,636 A
• Filed: 09/19/1997
• Issued: 05/25/1999
• Est. Priority Date: 09/20/1996
• Status: Expired due to Term

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Texas Heart Institute
• Inventors: Willerson, James T., Casscells, S. Ward III
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US08/934,260
• Time in Patent Office: 613 Days
• Field of Search: 607/96, 607/97, 607/98, 607/99, 606/27
• US Class Current: 607/96
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61F 2007/0088 Radiating heat
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body

Abstract

The present invention relates to methods for treating inflammation in body tissues. More specifically, certain disclosed methods relate to selectively inducing apoptosis in inflammatory immune cells. The methods are particularly suitable for treating inflamed atherosclerotic plaques. The techniques generally involve heating the cells with a catheter that is equipped to produce infrared radiation. The cells are heated for a sufficient time and at a sufficient temperature to induce programmed cell death.

Claims

1. A method of treating inflammation in vivo comprising heating an inflamed tissue at a temperature in the range of about 38.5°

C. to 44°

C.

2. The method of claim 1 wherein said inflamed tissue comprises an atherosclerotic plaque.

3. The method of claim 1 wherein said heating is accomplished by a heat source positioned within the lumen of a blood vessel.

4. The method of claim 1 wherein said heating is accomplished with a catheter.

5. The method of claim 1 wherein said heating comprises heating with infrared radiation.

6. The method of treating inflammation of claim 1 wherein said heating is at a temperature in the range of 41°

C. to 44°

C.

7. The method of claim 1 wherein said heating induces apoptosis in immune cells.

8. The method of claim 1 further comprising treating said inflamed tissue with a chemical agent.

9. The method of claim 1 wherein said treating further comprises treating said inflamed tissue with gamma-radiation.

10. The method of claim 1 wherein said heating step comprises treating said inflamed tissue with radiofrequency radiation.

11. The method of claim 1 wherein said treating further comprises treating said inflamed tissue with ultraviolet radiation.

12. The method of claim 1 wherein said heating step comprises treating said inflamed tissue with microwave radiation.

13. The method of claim 1 wherein said heating step comprises treating said inflamed tissue with a heated liquid.

14. A method for treating inflammation comprising heating inflamed tissue at a temperature in the range of 38.5°

C. to 41°

C.

15. A method for treating information comprising heating inflamed tissue for a period of time in the range of approximately 15 to 60 minutes.

16. The method of claim 15 wherein said heating occurs for a period of time in the range of approximately 15 to 30 minutes.

17. A method for treating inflammation comprising heating inflamed tissue and treating said inflamed tissue with a chemical agent wherein said chemical agent is a cytokine.

18. A method for treating inflammation comprising heating inflamed tissue and treating said inflamed tissue with a chemical agent wherein said chemical agent is a growth factor.

19. A method for treating inflammation comprising heating inflamed tissue and treating said inflamed tissue with a chemical agent wherein said chemical agent is a growth factor selected from the group consisting of insulin-like growth factor, vascular endothelial growth factor, fibroblast growth factor.

20. A method of treating an atherosclerotic plaque comprising an inflamed atherosclerotic plaque in the lumen of a blood vessel with a heat source having a temperature in the range of from about 38.5°

C. to 44°

C. for a period of time ranging from about 15 to 60 minutes and inducing apoptosis in a macrophage.

21. A method for inducing quiescence or apoptosis in inflammatory cells comprising the step of heating inflammatory cells in a blood vessel at about 38.5°

C. to 44°

C. for about 15 to 60 minutes.

22. The method of inducing apoptosis in inflammatory cells of claim 21 wherein said heating includes irradiating macrophages with infrared radiation whereby apoptosis is induced in said macrophages.

23. The method of claim 21 wherein said heating comprises using a catheter to heat macrophages in a blood vessel.

24. A method for inducing quiescence or apoptosis in inflammatory cells comprising the step of heating inflammatory cells in a blood vessel for fifteen (15) minutes.

25. A method for inducing quiescence or apoptosis in inflammatory cells comprising the step of heating inflammatory cells in a blood vessel in at a temperature of between approximately 41°

C. and 44°

C.

26. A method of treating an atherosclerotic plaque comprising the step of treating an atherosclerotic plaque with heat in the range of 38.5°

C. to 44°

C.

27. A method of treating inflammation comprising heating inflamed body tissue by heating a stent that is in thermal contact with the inflamed body tissue.

28. The method of treating inflammation of claim 27 wherein the said stent is heated by microwave radiation.

29. The method of treating inflammation of claim 27 wherein the said stent is heated by radiofrequency radiation.

30. A method of reducing the risk of death from myocardial infarction or stroke due to rupture of atherosclerotic plaque comprising treating an inflamed atherosclerotic plaque with heat in the range of 38°

C. to 44°

C.

31. The method of claim 30 wherein said treating comprises heating an inflamed atherosclerotic plaque in the range of about 38°

C. to 41°

C. whereby inflammation is reduced and/or apoptosis of cells within said plaque is induced.

32. The method of claim 30 wherein said treating comprises heating an inflamed atherosclerotic plaque in the range of 41°

C. to 44°

C.

33. The method of claim 30 wherein said method further comprises treating said plaque with a chemical agent chosen from the group consisting of cytokines and growth factors.

34. A method of decreasing or eliminating inflammation in a localized region of tissue comprising heating said region at about 38-44°

C. for about 5-60 minutes.

35. The method of claim 34 wherein said localized region is an inflamed atherosclerotic plaque.

36. The method of claim 34 wherein said localized region of tissue is a cluster of inflammatory cells.