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Electrochemical detector integrated on microfabricated capillary electrophoresis chips

  • US 5,906,723 A
  • Filed: 08/26/1996
  • Issued: 05/25/1999
  • Est. Priority Date: 08/26/1996
  • Status: Expired due to Term
First Claim
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1. In a microfabricated capillary electrophoresis chip including a substrate with an elongated separation channel with conductive means at each end of the channel for applying a separation voltage along the channel, the improvement comprising an integrated electrochemical detector having a thin film working electrode extending into said separation channel at or near the very end of said separation channel where the working electrode is close to ground potential and has minimal influence from the high electrophoresis potentials, in order to detect current generated by molecules undergoing redox reaction as they migrate past the thin film electrode after they have migrated the length of the channel, the portion of said thin film electrode extending into said channel being very narrow to minimize the electrophoresis voltage gradient which it senses, and a reference electrode spaced from said working electrode.

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