×

Mesenchymal stem cells for cartilage repair

  • US 5,906,934 A
  • Filed: 03/14/1995
  • Issued: 05/25/1999
  • Est. Priority Date: 03/14/1995
  • Status: Expired due to Term
First Claim
Patent Images

1. A method for growing new articular cartilage or articular cartilage and subchondral bone in a patient comprisingadministering to a site where articular cartilage or articular cartilage and subchondral bone is needed isolated mesenchymal stem cells seeded in a polymeric carrier suitable for proliferation and differentiation of the cells into articular cartilage or articular cartilage and subchondral bone,wherein said isolated mesenchymal stem cells are purified pluripotent mesenchymal stem cells, which cells are characterized by being substantially free of multinucleated myogenic lineage-committed cells, and which cells are predominantly stellate-shaped cells, wherein the mesenchymal stem cells form predominantly fibroblastic cells when contacted with muscle morphogenic protein in tissue culture medium containing 10% fetal calf serum and form predominantly branched multinucleated structures that spontaneously contract when contacted with muscle morphogenic protein and scar inhibitory factor in tissue culture with medium containing 10% fetal calf serum.

View all claims
  • 7 Assignments
Timeline View
Assignment View
    ×
    ×