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Endowing lymphocytes with antibody specificity

  • US 5,906,936 A
  • Filed: 05/04/1993
  • Issued: 05/25/1999
  • Est. Priority Date: 05/04/1988
  • Status: Expired due to Term
First Claim
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1. A mononuclear T-killer cell which expresses a chimeric receptor which permits said cell to selectively kill target cells bearing a predefined target antigen in a non-MHC restricted manner, said cell containing recombinant DNA encoding said chimeric receptor, said DNA comprising:

  • a. DNA coding for the two chains of the constant region of a T-cell receptor (TcR), said two chains being the α and

    β

    chains or the γ and

    δ

    chains, andb. DNA coding for the variable regions of the heavy and light chains of an antibody specific for the predefined target antigen, such that, when expressed, one of said heavy and light chains of said antibodies is attached to one of said two chains of said T-cell constant region and the other of said heavy and light chains of said antibodies is attached to the other of said two chains of said T-cell constant regions.

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