Compositions and methods for treating metabolic diseases characterized by hyperandrogenism and/or anovulation and/or infertility

• US 5,906,979 A
• Filed: 01/27/1998
• Issued: 05/25/1999
• Est. Priority Date: 01/27/1998
• Status: Expired due to Fees

• Current Assignee: INSMED Pharmaceuticals, Inc. (Insmed Incorporated)
• Original Assignee: INSMED Pharmaceuticals, Inc. (Insmed Incorporated)
• Inventors: Allan, Geoffrey
• Primary Examiner(s): JORDAN, KIMBERLY R
• Application Number:
  US09/014,398
• Time in Patent Office: 483 Days
• Field of Search: 514/25, 514/824
• US Class Current: 514/25
• CPC Class Codes: A61K 31/7004 Monosaccharides having only carbon, hydrogen and oxygen atoms
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/06 Antihyperlipidemics

Abstract

This invention relates to compositions and methods for decreasing the level of serum insulin, triglycerides, cholesterol, and/or free and total testosterone, and/or improving ovulation, and/or increasing progesterone and/or sex hormone binding globulin in mammals. This invention also relates to compositions and methods for treating metabolic diseases characterized by hyperinsulinemia, hyperandrogenism, hyperlipidemia and/or anovulation, such as polycystic ovary syndrome.

Claims

1. A method for decreasing the level of free and total testosterone in mammals suffering from metabolic diseases characterized by hyperandrogenism and/or anovulation, said method comprising the step of administering to a mammal an effective amount of D-chiro-inositol.

2. The method according to claim 1, wherein said mammal is a human.

3. The method according to claim 1, wherein said effective amount is between about 1 mg/kg of body weight of said mammal per day and about 1000 mg/kg of body weight of said mammal per day.

4. The method according to claim 1, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

5. A method for treating polycystic ovary syndrome, which comprises the step of administering to a mammal in need thereof an effective amount of D-chiro-inositol.

6. The method according to claim 5, wherein said mammal is a human.

7. The method according to claim 5, wherein said effective amount is between about 1 mg/kg of body weight of said mammal per day and about 1000 mg/kg of body weight of said mammal per day.

8. The method according to claim 5, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

9. A method for improving ovulation in mammals suffering from metabolic diseases characterized by hyperandrogenism and/or anovulation, said method comprising the step of administering to a mammal an effective amount of D-chiro-inositol.

10. The method according to claim 9, wherein said mammal is a human.

11. The method according to claim 9, wherein said effective amount is between about 1 mg/kg of body weight of said mammal per day and about 1000 mg/kg of body weight of said mammal per day.

12. The method according to claim 9, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

13. A method for increasing progesterone levels in mammals suffering from metabolic diseases characterized by hyperandrogenism pad/or anovulation, said method comprising the step of administering to a mammal an effective amount of D-chiro-inositol.

14. The method according to claim 13, wherein said mammal is a human.

15. The method according to claim 13, wherein said effective amount is between about 1 mg/kg of body weight of said mi per day and about 1000 mg/kg of body weight of said mammal per day.

16. The method according to claim 13, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

17. A method for increasing sox hormone binding globulin in mammals suffering from metabolic diseases characterized by hyperandrogenism and/or anovulation, said method comprising the step of administering to a mammal an effective amount of D-chiro-inositol.

18. The method according to claim 17, wherein said mammal is a human.

19. The method according to claim 17, wherein said effective amount is between about 1 mg/kg of body weight of said mammal per day and about 1000 mg/kg of body weight of said mammal per day.

20. The method according to claim 17, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

21. A method for treating menstrual irregularity in s suffering from metabolic diseases characterized by hyperandrogenism and/or anovulation, said method comprising the step of administering to a mammal an effective amount of D-chiro-inositol.

22. The method according to claim 21, wherein said mammal is a human.

23. The method according to claim 21, wherein said effective amount is between about 1 mg/kg of body weight of said mammal per day and about 1000 mg/kg of body weight of said mammal per day.

24. The method according to claim, 21, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

34. The method according to claim 23, wherein said mammal is a human.

35. The method according to claim 23, wherein said effective amount is between about 1 mg/kg of body weight of said mammal per day and about 1000 mg/kg of body weight of said mammal per day.

36. The method according to claim 23, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

25. A method for treating infertility in mammals suffering from metabolic diseases characterized by hyperandrogenism and/or anovulation, said method comprising the step of administering to a mammal an effective amount of D-chiro-inositol.

26. The method according to claim 25, wherein said mammal is a human.

27. The method according to claim 25, wherein said effective amount is between about 1 mg/kg of body weight of said mammal per day and about 1000 mg/kg of body weight of said mammal per day.

28. The method according to claim 25, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

29. A method for treating hyperandrogenism and/or anovulation associated with polycystic ovary syndrome in mammals, said method comprising the stop of administering to a mammal an effective amount of D-chiro-inositol.

30. The method according to claim 29, wherein said mammal is a human.

31. The method according to claim 29, wherein said effective amount is between about 1 mg/kg of body weight of said mammal per day and about 1000 mg/kg of body weight of said mammal per day.

32. The method according to claim 29, wherein said effective amount is between about 2 mg/kg of body weight of said mammal per day and about 20 mg/kg of body weight of said mammal per day.

33. A method for treating amenorrhea or oligomenorrhea in mammals suffering form metabolic diseases characterized by hyperandrogenism and/or anovulation, said method comprising the step of administering to a mammal an effective amount of D-chiro-inositol.