Nutritional formulations containing Lacto-N-neoTetraose

• US 5,906,982 A
• Filed: 03/31/1997
• Issued: 05/25/1999
• Est. Priority Date: 03/31/1997
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Prieto, Pedro A., Kroening, Terry A.
• Primary Examiner(s): Krass, Frederick
• Application Number:
  US08/829,220
• Time in Patent Office: 785 Days
• Field of Search: 726/601, 726/602, 726/606, 726/607, 726/608, 726/648, 726/658, 726/801, 514/61
• US Class Current: 514/61
• CPC Class Codes: A23C 9/203 containing bifidus-active substances, e.g. lactulose; containing oligosaccharides
• CPC Class Codes: A23L 29/30 containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin products from apiculture A23L21/20; artificial sweetening agents A23L27/30
• CPC Class Codes: A23L 33/125 containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates indigestible substances A23L33/21
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/154 Water
• CPC Class Codes: A23V 2250/156 Mineral combination undefined extract A23V2250/1638
• CPC Class Codes: A23V 2250/1578 Calcium
• CPC Class Codes: A23V 2250/1582 Chlorine
• CPC Class Codes: A23V 2250/1592 Iron
• CPC Class Codes: A23V 2250/16 Potassium
• CPC Class Codes: A23V 2250/161 Magnesium
• CPC Class Codes: A23V 2250/1618 Phosphorus
• CPC Class Codes: A23V 2250/1642 Zinc
• CPC Class Codes: A23V 2250/1872 Linoleic acid
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A23V 2250/304 Choline
• CPC Class Codes: A23V 2250/542 Animal Protein
• CPC Class Codes: A23V 2250/60 : Sugars, e.g. mono-, di-, tri-, tetra-saccharides
• CPC Class Codes: A23V 2250/70 : Vitamins
• CPC Class Codes: A23V 2250/702 : Vitamin A
• CPC Class Codes: A23V 2250/704 : Vitamin B
• CPC Class Codes: A23V 2250/705 : Vitamin B5 pantothenic acid
• CPC Class Codes: A23V 2250/708 : Vitamin C
• CPC Class Codes: A23V 2250/71 : Vitamin D
• CPC Class Codes: A23V 2250/712 : Vitamin E
• CPC Class Codes: A23V 2250/714 : Vitamin K
• CPC Class Codes: Y10S 426/801 : Pediatric

Abstract

A nutritional formulation containing an effective amount of Lacto-N-neoTetraose to simulate the growth and/or metabolic activity of Bifidobacterium is provided. A process of inhibiting bacterial infections including the step of feeding the nutritional composition to a subject is also provided.

Claims

1. A synthetic nutritional composition comprising Lacto-N-neoTetraose in an amount sufficient to stimulate the growth of Bifidobacterium infantis, the metabolic activity of Bifidobacterium infantis or both properties thereof.

2. The composition of claim 1 further comprising edible macronutrients.

3. The composition of claim 2 wherein the edible macronutrients are formulated for feeding to an infant.

4. The composition of claim 3 wherein the macronutrients comprise one or more of coconut oil, soy oil, mono- or diglycerides, glucose, edible lactose, electrodialysed whey or electrodialysed skim milk, milk whey, soy protein, or other protein hydrolysates.

5. The composition of claim 1 that is in liquid form.

6. The composition of claim 1 that is in solid form.

7. The composition of claim 1 further comprising one or more of vitamins A, C, D, E on B complex.

8. The composition of claim 1 further comprising one or more of minerals calcium, magnesium, manganese, sodium, potassium, phosphorus, copper, zinc, chloride, iodine, selenium or iron.

9. The composition of claim 1 containing from about 0.05 to about 2.0 mg/ml of Lacto-N-neoTetraose.

10. The composition of claim 9 containing from about 0.075 to about 1.0 mg/ml of Lacto-N-neoTetraose.

11. The composition of claim 10 containing from about 0.1 to about 0.5 mg/ml of Lacto-N-neoTetraose.

12. A synthetic nutritional composition comprising Lacto-N-neoTetraose in an amount sufficient to stimulate the growth of Bifidobacterium infantis, the metabolic activity of Bifidobacterium infantis, or both properties thereof;

edible macronutrients formulating for feeding to an infant and comprising one or more of coconut oil, soy oil, mono- or diglycerides, glucose, edible lactose, electrodialyzed whey, electrodialyzed skim milk or milk whey;

one or more of vitamins A, C, D, E or B complex; and

one or more of minerals calcium, magnesium, manganese, sodium, potassium, phosphorus, copper, zinc, chloride, iodine, selenium or iron.