Amino alcohol derivative and method for preparing the same
First Claim
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1. An amino alcohol derivative represented by the following formula (2):
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space="preserve" listing-type="equation">R.sup.2 --CH.sub.2 --(C*)H(HNP.sup.1)--(C*)H(OH)--R.sup.1 (
2)whereinC* is an asymmetric carbon atom;
P1 is an amino-protecting group selected from the group consisting of benzvloxycarbonyl groups which may have at least one substituent, alkoxycarbonyl groups which may have at least one substituent, and a benzenesulfonyl group;
R1 is an alkyl group, a cycloalkyl group or an aryl group; and
R2 is ##STR5## wherein R5 is a hydrogen atom or at least one substituent, and if two or more said substituents, said substituents are the same or different, wherein said substituent is a hydroxyl group, a lower alkyl group, a lower alkoxyl group, a hydroxyl-lower-alkyl group, a carboxyl group, a (lower alkoxyl) carbonyl group, an aralkyl group, a piperidino group, an acyloxy group, an amino group or an amino-lower-alkyl group; and
m is an integer of 2 to 6.
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Abstract
Amino alcohol derivatives with a primary amino group or a substituted amino group influence the synthesis of glycolipids and have antiviral, antitumor, metastasis inhibiting and neural cell growth enhancing functions. The amino alcohol derivatives are useful in preparing 2-acylamino alcohol derivatives.
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Citations
6 Claims
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1. An amino alcohol derivative represented by the following formula (2):
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space="preserve" listing-type="equation">R.sup.2 --CH.sub.2 --(C*)H(HNP.sup.1)--(C*)H(OH)--R.sup.1 (
2)wherein C* is an asymmetric carbon atom; P1 is an amino-protecting group selected from the group consisting of benzvloxycarbonyl groups which may have at least one substituent, alkoxycarbonyl groups which may have at least one substituent, and a benzenesulfonyl group; R1 is an alkyl group, a cycloalkyl group or an aryl group; and R2 is ##STR5## wherein R5 is a hydrogen atom or at least one substituent, and if two or more said substituents, said substituents are the same or different, wherein said substituent is a hydroxyl group, a lower alkyl group, a lower alkoxyl group, a hydroxyl-lower-alkyl group, a carboxyl group, a (lower alkoxyl) carbonyl group, an aralkyl group, a piperidino group, an acyloxy group, an amino group or an amino-lower-alkyl group; and m is an integer of 2 to 6. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification