Retroperfusion catheter apparatus and method

• US 5,908,407 A
• Filed: 07/25/1997
• Issued: 06/01/1999
• Est. Priority Date: 07/25/1997
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Neuroperfusion, Inc.
• Inventors: Frazee, John G., Cornett, David C., Evans, Scott M.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US08/900,967
• Time in Patent Office: 676 Days
• Field of Search: 604/101, 604/65-67, 604/27, 604/30, 604/31, 604/49-53, 604/280, 604/96-100, 606/192, 606/194, 600/16, 600/17, 600/18
• US Class Current: 604/101.01
• CPC Class Codes: A61M 2025/0079 Separate user-activated means, e.g. guidewires, guide tubes, balloon catheters or sheaths, for sealing off an orifice, e.g. a lumen or side holes, of a catheter
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

A catheter for retroprofusing a venous junction formed by first, second and third veins, includes an elongate tube having a plurality of channels including a through-lumen extending between a proximal end and a distal end. A proximal balloon is inflatable to partially occlude the third vein, while a distal balloon is inflatable to partially occlude the second vein. An operative region of the catheter between the first and second balloons is adapted to pressurize the venous junction with arterial blood to produce retrograde blood flow in the first vein.

Claims

1. A catheter for a retroperfusing a venous junction defined by a first vein providing normal blood flow into the junction, and a second and third vein each providing normal blood flow away from the junction, the catheter comprising:

an elongate tube having an axis extending between a proximal end and a distal end;

portions of the tube defining a plurality of channels, including a through-lumen extending from the proximal end through the distal end of the tube;

a first occlusion device disposed in proximity to the distal end of the tube and adapted to at least partially occlude the third vein;

a second occlusion device disposed in proximity to the first occlusion device and adapted to at least partially occlude the second vein with the venous junction disposed between the first occlusion device and the second occlusion device; and

a retroperfusion lumen included in the channels and having an outlet between the first occlusion device and the second occlusion device, the retroperfusion lumen being adapted to receive arterial blood or pharmacological agents under pressure in order to induce retrograde blood flow in the first vein.

2. The catheter recited in claim 1, further comprising:

a pressure lumen included in the channels of the tube, the pressure lumen providing at the proximal end of the tube an indication of the fluid pressure at the venous junction.

3. The catheter recited in claim 2, further comprising:

at least one radiopaque marker carried by the tube and having properties for facilitating placement of the first balloon relative to the venous junction.

4. The catheter recited in claim 3, further comprising:

portions of the tube defining a first port providing fluid communication between the retroperfusion lumen and the venus junction; and

portions of the tube defining at least one second port spaced from the first port and providing fluid communication between the retroperfusion lumen and the venus junction.

5. The catheter recited in claim 4, further comprising portions of the tube defining a soft tip distally of the first balloon.

6. The catheter recited in claim 5, further comprising:

at least one inflation lumen included among the channels of the tube, the at least one inflation lumen providing fluid communication between the proximal end of the tube and at least one of the balloons, for at least partially inflating the at least one balloon in response to the fluid pressure at the venous junction.

7. A catheter combination for retroperfusing a venous junction defined by a first vein providing normal blood flow into the junction and a second and third vein each providing normal blood flow away from the junction, comprising:

an elongate tube having an axis extending between a proximal end and a distal end;

portions of the tube defining a plurality of channels including a through-lumen extending from the proximal end of the tube through the distal end of the tube;

a first balloon disposed in proximity to the distal end of the tube and adapted to partially occlude the third vein;

a second balloon disposed in proximity to the first balloon and adapted to partially occlude the second vein, the first balloon and the second balloon defining an operative region of the tube in proximity to the venous junction;

a retroperfusion lumen included among the channels and adapted to provide fluid communication between the proximal end of the tube and the venous junction; and

a blood pump providing a flow of arterial blood into the retroperfusion lumen at the proximal end of the tube, the pump having properties for pressurizing the flow of arterial blood at the venous junction so as to produce a retrograde flow of the blood in the first vein.

8. The catheter assembly recited in claim 7 further comprising:

a pressure lumen included among the channels of the tube and extending between the proximal end of the tube and the operative region of the tube;

portions of the tube defining at least one port in the operative region of the tube, the at least one port providing fluid communication between the retroperfusion lumen and the venous junction; and

a pressure transducer disposed in fluid communication with the pressure lumen, the pressure transducer providing an indication of the fluid pressure at the venous junction.

9. The catheter assembly recited in claim 8, further comprising:

at least one inflation lumen included among the channels and extending between the proximal end of the tube and the first balloon;

an inflator providing fluid under pressure at the proximal end of the tube, the inflator being adapted to inflate and deflate the first balloon to control the occlusion of the third vein.

10. A method for retroperfusing a venous bed in the brain of a patient, the venous bed communicating with a venous junction defined by a first vein providing antegrade flow into the junction, and second and third veins providing antegrade blood flow away from the junction, the method comprising the steps of:

introducing into the second vein a catheter having a first balloon and a second balloon defining an operative region of the catheter, and a plurality of channels including a retroperfusion lumen exiting the catheter in the operative region, and an inflation lumen providing fluid communication with at least the first balloon;

positioning the catheter with the first balloon disposed in the third vein and the second balloon disposed in the second vein with the operative region of the catheter disposed in proximity to the venous junction;

pressurizing the retroperfusion lumen with arterial blood in order to provide an elevated blood pressure at the venous junction sufficient to induce retrograde blood flow in the first vein; and

pressurizing the inflation lumen with a fluid to inflate at least the first balloon in order to control the antegrade blood flow from the venous junction.

11. The method recited in claim 10 further comprising the steps of:

providing a pressure lumen in the catheter;

placing a pressure transducer in fluid communication with the pressure lumen, the transducer providing an indication of pressure at the venous junction; and

during the second pressurizing step, monitoring the indication of the pressure transducer to control the antegrade blood flow from the venous junction.

12. The method recited in claim 11 wherein the controlling step further comprises the step of independently controlling the inflation of the first balloon and the second balloon in response to the indication of the pressure transducer.