Chlorhexidine gluconate-containing, stabilized aqueous pharmaceutical preparations
First Claim
1. An aqueous pharmaceutical composition comprising an aqueous solution of stably maintained chlorhexidine gluconate, chloride ion and at least one pharmaceutically acceptable polycarboxylic acid of formula I:
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space="preserve" listing-type="equation">HOOC--(CR.sub.i1 R.sub.i2)n--COOH (I)wherein n denotes an integer of 1 to 3;
i denotes a positive integer not more than n;
R11, and R12, when n=1, independently from each other, denote H, --OH or --COOH;
each of R11, R12, R21 and R22, when n=2, denotes H, --OH or --COOH,with the proviso that not all of them denote H simultaneously; and
each of R11, R12, R21, R22, R31 and R32, when n=3, denotes H, --OH or --COOH, with the proviso that two adjacent carbons in no case contain four hydrogen atoms in total;
or a pharmaceutically acceptable salt thereof.
1 Assignment
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Accused Products
Abstract
An aqueous pharmaceutical preparation is provided containing chloride ion and stably containing chlorhexidine gluconate, characterized in that said preparation further contains at least one pharmaceutically acceptable polycarboxylic acid of the formula I:
HOOC--(CR.sub.i 1 --CR.sub.i 2)n --COOH (I)
wherein n is an integer 1, 2 or 3; i is a positive integer not more than n; R11 and R12, when n=1, independently from each other, are H, --OH or --COOH; each of R11, R12, R21 and R22, when n=2, is H, --OH or --COOH, but not all of them are H simultaneously; and each of R11, R12, R21, R22, R31 and R32, when n=3, is H, --OH or --COOH, but two adjacent carbons in no case contain four hydrogen atoms in total; or a pharmaceutically acceptable salt thereof.
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Citations
24 Claims
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1. An aqueous pharmaceutical composition comprising an aqueous solution of stably maintained chlorhexidine gluconate, chloride ion and at least one pharmaceutically acceptable polycarboxylic acid of formula I:
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space="preserve" listing-type="equation">HOOC--(CR.sub.i1 R.sub.i2)n--COOH (I)wherein n denotes an integer of 1 to 3;
i denotes a positive integer not more than n;
R11, and R12, when n=1, independently from each other, denote H, --OH or --COOH;
each of R11, R12, R21 and R22, when n=2, denotes H, --OH or --COOH,with the proviso that not all of them denote H simultaneously; and
each of R11, R12, R21, R22, R31 and R32, when n=3, denotes H, --OH or --COOH, with the proviso that two adjacent carbons in no case contain four hydrogen atoms in total;
or a pharmaceutically acceptable salt thereof. - View Dependent Claims (2, 3, 4, 5, 6, 12, 13, 16, 17, 18, 19, 20, 21)
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7. A method for prevention of precipitation of chlorhexidine gluconate in an aqueous solution containing chloride ion and chlorhexidine gluconate, comprising adding to said aqueous solution at least one polycarboxylic acid of the formula I:
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space="preserve" listing-type="equation">HOOC--(CR.sub.i1 R.sub.i2)n--COOH (I)wherein n denotes an integer of 1 to 3;
i denotes a positive integer not more than n;
R11 and R12, when n=1, independently from each other, denote H, --OH or --COOH;
each of R11, R12, R21 and R22, when n=2, denotes H, --OH or --COOH, with the proviso that not all of them denote H simultaneously; and
each of R11, R12, R21, R22, R31 and R32, when n=3, denotes H, --OH or --COOH, with the proviso that two adjacent carbons in no case contain four hydrogen atoms in total;
or a pharmaceutically acceptable salt thereof. - View Dependent Claims (8, 9, 10, 11, 14, 15, 22, 23, 24)
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Specification