Coulometric analysis method and a device therefor
First Claim
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1. An apparatus for coulometric analysis for the quantitative determination of a substance in a sample comprising:
- a first electrode containing at least a mediator, wherein said mediator is capable of reacting with said substance to produce a first electroactive species;
a second electrode containing a second electroactive species, wherein said first electroactive species and said second electroactive species have an electrochemical potential difference;
an ion-permeable membrane situated between said first and said second electrodes; and
means for measuring an electrical quantity generated by said electrochemical potential difference without application of an external power source, whereby said electrical quantity is used to quantify said substance.
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Abstract
The present invention provides a rapid coulometric analysis for the quantitative determination of a sample substance with high reproducibility without any application of voltage etc. from the outside, as well as a galvanic cell and a device for use in said coulometric analysis. According to the present invention, a wide variety of components can be analyzed by selection of electroactive substance introduced into the galvanic cell. The present invention enables a simple and easy analysis for food components such as glutamic acid, ascorbic acid, etc., water quality such as COD, etc.
71 Citations
28 Claims
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1. An apparatus for coulometric analysis for the quantitative determination of a substance in a sample comprising:
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a first electrode containing at least a mediator, wherein said mediator is capable of reacting with said substance to produce a first electroactive species; a second electrode containing a second electroactive species, wherein said first electroactive species and said second electroactive species have an electrochemical potential difference; an ion-permeable membrane situated between said first and said second electrodes; and means for measuring an electrical quantity generated by said electrochemical potential difference without application of an external power source, whereby said electrical quantity is used to quantify said substance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An apparatus for coulometric analysis for the quantitative determination of a substance in a sample comprising:
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a first electrode containing at least a mediator, wherein said mediator is capable of reacting with said substance to produce a first electroactive species; a second electrode containing a second electroactive species; an ion-permeable membrane situated between said first and said second electrodes; and means for measuring an electrical quantity generated by at least one self-driven reaction between said first electroactive species and said second electroactive species, whereby said electrical quantity is used to quantify said substance. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. An apparatus for coulometric analysis for the quantitative determination of an aqueous substance in a sample comprising:
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a first electrode having a hydrophilic and conductive material that is impregnated with at least a mediator, wherein said mediator is capable of reacting with said sample to produce a first electroactive species; a second electrode having a hydrophilic and conductive material that is impregnated with a second electroactive species, wherein said first electroactive species and said second electroactive species have an electrochemical potential difference; an ion-permeable membrane situated between said first and said second electrodes; and means for measuring an electrical quantity generated by said electrochemical potential difference without application of an external power source, whereby said electrical quantity is used to quantify said substance. - View Dependent Claims (20, 21, 22)
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23. An apparatus for coulometric analysis for the quantitative determination of an aqueous non-electroactive substance in a sample comprising:
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a first electrode containing a first aqueous solution including at least the sample and a mediator, wherein said mediator is capable of reacting with said non-electroactive sample to produce a first electroactive species; a second electrode containing a second electroactive species; an ion-permeable membrane situated between said first and said second electrodes; and means for measuring an electrical quantity generated by a potential difference between said first and said second electroactive species without application of an external power source, whereby said electrical quantity is used to quantify said substance. - View Dependent Claims (24, 25, 26, 27, 28)
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Specification