.sup.23 NA and .sup.39 K imaging of the heart

• US 5,910,112 A
• Filed: 04/11/1997
• Issued: 06/08/1999
• Est. Priority Date: 11/08/1996
• Status: Expired due to Fees

• Current Assignee: Johns Hopkins University, Northwestern University
• Original Assignee: Northwestern University
• Inventors: Parrish, Todd B., Judd, Robert M.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/827,809
• Time in Patent Office: 788 Days
• Field of Search: 324/318, 324/322, 324/309, 324/307, 600/410
• US Class Current: 600/410
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence

Abstract

Methods for increasing the efficiency of ²³ Na and ³⁹ K imaging of biological tissue are provided. For maximum efficiency, the receiver bandwidth is set equal to or less than the quantity N_ro /T*2. Methods for assessing cardiac tissue viability using ²³ Na imaging are also provided.

Claims

1. A process of increasing the efficiency of ²³ Na magnetic resonance imaging of biological tissue, the process including the step of acquiring ²³ Na images using magnetic resonance imaging with a receiver bandwith equal to R(N_ro /T*_2Na) where R is an integer from 1 to about 5 and N_ro is the number of readout samples.

2. The process of claim 1 wherein R is from about 1 to about 3.

3. The process of claim 1 wherein R is from about 1 to about 2.

4. The process of claim 1 wherein the bandwidth is from about 500 Hz to about 10,000 Hz.

5. The process of claim 4 wherein the bandwidth is from about 1,000 Hz to about 5,000 Hz.

6. The process of claim 5 wherein the bandwidth is from about 2,500 Hz to about 5,000 Hz.

7. The process of claim 6 wherein the bandwidth is from about 2,500 Hz to about 3,000 Hz.

8. The process of claim 1 wherein ²³ Na images are acquired using a 1.5 T scanner.

9. The process of claim 8 wherein the images are acquired in from about 15 to about 60 minutes.

10. The process of claim 1 wherein ²³ Na images are acquired using a 3.0 T scanner.

11. The process of claim 10 wherein the images are acquired in from about 30 to about 45 minutes.

12. The process of claim 1 wherein ²³ Na images are acquired using a 4.0 T scanner.

13. The process of claim 12 wherein the images are acquired in about 30 minutes.

14. The process of claim 1 wherein the biological tissue is located in a living organism.

15. The process of claim 14 wherein the biological tissue is a human heart.

16. A process of increasing the efficiency of ³⁹ K magnetic resonance imaging of biological tissue, the process including the step of acquiring ³⁹ K images using magnetic resonance imaging with a receiver bandwith equal or less than R(N_ro /T*_2K) where R is an integer from 1 to about 5 and N_ro is the number of readout samples.

17. The process of claim 16 wherein the bandwidth is from about 1,000 Hz to about 30,000 Hz.

18. The process of claim 17 wherein the bandwidth is about 8,000 Hz.