Highly selective chemical sensor

• US 5,910,286 A
• Filed: 10/17/1996
• Issued: 06/08/1999
• Est. Priority Date: 02/21/1995
• Status: Expired due to Fees

• Current Assignee: Thomson-CSF (Thales SA)
• Original Assignee: Thomson-CSF (Thales SA)
• Inventors: Lipskier, Jean-Fran.cedilla.ois
• Primary Examiner(s): DAVENPORT, AVIS MICHELLE
• Application Number:
  US08/722,147
• Time in Patent Office: 964 Days
• Field of Search: 422/68.1
• US Class Current: 422/68.1
• CPC Class Codes: G01N 2291/0256 Adsorption, desorption, surface mass change, e.g. on biosensors
• CPC Class Codes: G01N 2291/0423 Surface waves, e.g. Rayleigh waves, Love waves
• CPC Class Codes: G01N 2291/0426 Bulk waves, e.g. quartz crystal microbalance, torsional waves
• CPC Class Codes: G01N 2291/0427 Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever
• CPC Class Codes: G01N 29/022 Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices microdevices per se B81B

Abstract

The invention relates to a highly selective chemical sensor comprising an acoustic wave transducer and a sensitive layer of so-called "molecular fingerprint" material. This is a macroporous crosslinked material having cavities whose steric and functional configuration is specifically suited to capturing molecular and/or ionic species.

Claims

1. A chemical sensor which is selective for a species G comprising an acoustic wave transducer and a sensitive layer on a surface of an element of the transducer, wherein the sensitive layer comprises a macroporous, crosslinked molecular fingerprint material which has cavities whose steric and functional configuration is specifically suited to capturing species G in the cavities, said sensitive layer and the cavities therein having been prepared by in situ polymerization of polymerizable monomers and crosslinking agents as a uniform film upon said surface.

2. Chemical sensor according to claim 1, wherein the molecular fingerprint material is a highly crosslinked organic polymer obtained by polymerization of a composition comprising one or more monomers that are crosslinkable in the presence of an extractable species G'"'"' whose chemical structure is similar or identical to that of species G.

3. Chemical sensor according to claim 2 wherein the species G'"'"' are molecules or ions or a combination of molecules and/or ions of given stoichiometry.

5. Chemical sensor according to claim 1, wherein the transducer is a surface wave transducer, comprising a piezoelectric material on which two interlocking series of electrodes are placed, separated by a surface on which is deposited the sensitive layer.

8. Chemical sensor according to claim 1 comprising an intermediate layer located between the sensitive layer and the transducer, ensuring the creation of strong chemical interactions between the sensitive layer and the transducer.

9. Chemical sensor according to claim 8, wherein the intermediate layer comprises silanes of general formula R_n SIX_n-4, with X being a hydrolysable group, R a non-hydrolysable organic group having functions capable of reacting with the monomers used to obtain the crosslinked polymer, the said intermediate layer promoting the adhesion of the sensitive layer to a piezoelectric substrate.

4. A chemical sensor which is selective for a species G comprising an acoustic wave transducer and a sensitive layer, wherein the sensitive layer comprises a macroporous, crosslinked molecular fingerprint material which has cavities whose steric and functional configuration is specifically suited to capturing species G in the cavities and wherein the transducer is a volume acoustic wave transducer comprising a piezoelectric material inserted between two electrodes, at least one of the electrodes being coated with the sensitive layer.

6. A chemical sensor which is selective for a species G comprising an acoustic wave transducer and a sensitive layer, wherein the sensitive layer comprises a macroporous, crosslinked molecular fingerprint material which has cavities whose steric and functional configuration is specifically suited to capturing species G in the cavities and wherein the acoustic wave transducer is a surface wave transducer, comprising a piezoelectric material on which two interlocking series of electrodes are placed, separated by a surface on which is deposited the sensitive layer, the piezoelectric material being a thin film of piezoelectric material, the sensitive layer being deposited at the surface of the film so as to generate acoustic waves of Lamb wave type.

7. A chemical sensor which is selective for a species G comprising an acoustic wave transducer and a sensitive layer, wherein the sensitive layer comprises a macroporous, crosslinked molecular fingerprint material which has cavities whose steric and functional configuration is specifically suited to capturing species G in the cavities and wherein the acoustic wave transducer is a surface wave transducer, comprising a piezoelectric material on which two interlocking series of electrodes are placed, separated by a surface on which is deposited the sensitive layer, and further wherein the transducer comprises an intermediate layer between the sensitive layer and the piezoelectric material, in which the acoustic waves are confined.

10. A chemical sensor which is selective for a species G comprising an acoustic wave transducer and a sensitive layer wherein the sensitive layer comprises a macroporous, crosslinked molecular fingerprint material which has cavities whose steric and functional configuration is specifically suited to capturing species G in the cavities, the chemical structure further comprising an intermediate layer located between the sensitive layer and the transducer, ensuring the creation of strong chemical interactions between the sensitive layer and the transducer wherein the intermediate layer comprises compounds of RSH or RS-SR'"'"' type, with R and R'"'"' being non-hydrolysable organic groups having functions capable of reacting with the monomers used to obtain the crosslinked polymer, the said intermediate layer promoting adhesion of the sensitive layer to a metal electrode.

11. A chemical sensor which is selective for a species G comprising an acoustic wave transducer and a sensitive layer wherein the sensitive layer comprises a macroporous, crosslinked molecular fingerprint material which has cavities whose steric and functional configuration is specifically suited to capturing species G in the cavities, wherein the molecular fingerprint material is a highly crosslinked organic polymer obtained by polymerization of a composition comprising one or more monomers that are crosslinkable in the presence of species G'"'"' whose chemical structure is similar or identical to that of species G the chemical sensor further comprising a combination of a chemical sensor defined above, and a chemical sensor comprising an acoustic wave transducer and a layer consisting of a highly crosslinked polymer identical to that of the sensitive layer but obtained in the absence of species G'"'"'.

12. A process for producing a sensor according to claim 11, comprising the steps of:

the production, through the agency of a first mask which leaves a first area of a substrate free, of a first component of molecular fingerprint material, wherein the substrate allows the propagation of acoustic waves;

the production, through the agency of a second mask which leaves a second area of the substrate free, of a second component of material crosslinked in the absence of a gauge molecule;

the production on either side of the first area and the second area of acoustic wave inducer and/or receptor means.

13. Process for producing a sensor according to claim 11, comprising the following steps:

a) preparation on a substrate which allows the propagation of acoustic waves with an alternation of a first layer of resin for photolithography, of a metal layer and of a second layer of resin for photolithography;

b) elimination of the second layer of resin in a first area;

c) etching of the metal layer in the first area;

d) attack of the first layer of resin in the first area and optionally of the rest of the second layer of resin;

e) exposure of the substrate in the first area during attack of the first layer of resin;

f) preparation, on the substrate in the first area, of a first component made of molecular fingerprint material;

g) preparation of a third layer of resin;

h) elimination of the third layer of resin in a second area;

i) etching of the metal layer in the second area;

j) attack of the first layer of resin in the second area and optionally of the rest of the third layer of resin;

k) exposure of the substrate in the second area during attack of the first layer of resin;

1) preparation, on the substrate in the second area, of a second component made of material crosslinked in the absence of gauge molecule;

m) elimination of the metal layer and of the first layer of resin.

14. Process according to claim 12 wherein the second component is made of material identical in composition to that of the first component, but is polymerized and crosslinked in the absence of a gauge molecule.

15. Process according to claim 13, further comprising producing means for inducing at least one acoustic wave in said first and second areas of the substrate.

16. Process according to claim 15, further comprising production, on either side of the first area and the second area, of acoustic wave inducer/receptor means.

17. Process according to claim 16, further comprising production, on either side of the first area and the second area, of conductive electrodes.

18. Process according to claim 13, wherein the second component is made of material identical in composition to that of the first component, but is polymerized and crosslinked in the absence of a gauge molecule.