Treatment of ischemic cardiac malfunction
First Claim
1. A method for increasing coronary perfusion in a mammalian host comprising administering to the host in need thereof an effective amount of a glycosidic hypothalamic inhibitory factor wherein said factor has been purified to homogeneity.
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Abstract
The present invention is based on the unexpected discoveries that hypothalamic inhibitory factor (HIF) has a positive inotropic effect in a whole organ preparation, such as an isolated perfused heart, and that HIF, to a greater extent than ouabain, dilates the coronary arteries in the isolated perfused heart as manifested in increased coronary flow in hearts treated with HIF. The present invention relates to a method for increasing coronary perfusion in a mammalian host comprising administering to the host in need thereof an effective amount of hypothalamic inhibitory factor (HIF). The invention also relates to a method for producing an increased coronary vasodilatory effect in a mammalian host comprising administering to a mammalian host in need thereof an effective amount of HIF. The method of the present invention can be used to prevent and/or treat ischemic cardiac malfunction and coronary artery restenosis.
67 Citations
3 Claims
- 1. A method for increasing coronary perfusion in a mammalian host comprising administering to the host in need thereof an effective amount of a glycosidic hypothalamic inhibitory factor wherein said factor has been purified to homogeneity.
Specification
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- Resources
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Current AssigneeThe General Hospital Corporation (Mass General Brigham, Inc.)
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Original AssigneeThe General Hospital Corporation (Mass General Brigham, Inc.)
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InventorsHaupert, Garner T. Jr.
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Primary Examiner(s)Goldberg, Jerome D.
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Application NumberUS08/866,712Time in Patent Office739 DaysField of Search514/25US Class Current514/25CPC Class CodesA61K 31/704 attached to a condensed car...A61P 9/10 for treating ischaemic or a...
