Iodothyronine polymers
First Claim
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1. A substantially pure synthetic iodothyronine copolymer of the formula ##STR9## wherein each X independently represents the residue of a naturally occurring α
- -amino acid, or a racemate therof;
each Z independently represents the residue of a naturally occurring α
-amino acid, or a racemate therof;
k and n are each integers ≧
0;
m is an integer between 5 and 400;
p is an integer ≧
1;
Y represents an amino acid residue having the structure ##STR10## wherein A is iodo and B, C and D are independently hydrogen or iodo, and wherein X and Z together comprise up to 80% of the units of the copolymer.
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Abstract
Iodothyronine polymers having a plurality of recurring units of formula I ##STR1## in which A is iodo and B, C and D are independently H or iodo are described. Polymers in which A and C are iodo and B and D are independently H or iodo and in which substantially all of the recurring units are L-stereoisomers, have utility in treating thyroid hormone deficiencies.
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Citations
4 Claims
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1. A substantially pure synthetic iodothyronine copolymer of the formula ##STR9## wherein each X independently represents the residue of a naturally occurring α
- -amino acid, or a racemate therof;
each Z independently represents the residue of a naturally occurring α
-amino acid, or a racemate therof;k and n are each integers ≧
0;m is an integer between 5 and 400; p is an integer ≧
1;Y represents an amino acid residue having the structure ##STR10## wherein A is iodo and B, C and D are independently hydrogen or iodo, and wherein X and Z together comprise up to 80% of the units of the copolymer. - View Dependent Claims (4)
- -amino acid, or a racemate therof;
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2. An iodothyronine copolymer consisting of at least one monomer unit X and at least 5 monomer units Y, wherein
X represents the residue of a naturally occurring α - -amino acid;
Y represents an amino acid residue having the structure ##STR11## wherein A is iodo and B, C and D are independently hydrogen or iodo; and
wherein said monomer units are linked to one another via a peptide bond between the α
-amino group of one amino acid, and the carboxyl group of the adjacent amino acid, and wherein said copolymer bears an N-terminal amino group, and a C-terminal carboxy group. - View Dependent Claims (3)
- -amino acid;
Specification