Automated syringe filling system for radiographic contrast agents and other injectable substances

• US 5,911,252 A
• Filed: 04/29/1997
• Issued: 06/15/1999
• Est. Priority Date: 04/29/1997
• Status: Expired due to Fees

• Current Assignee: Douglas Cassel
• Original Assignee: Douglas Cassel
• Inventors: Cassel, Douglas
• Primary Examiner(s): Jacyna, J. Casimer
• Assistant Examiner(s): Douglas, Steven O.
• Application Number:
  US08/845,812
• Time in Patent Office: 777 Days
• Field of Search: 141/9, 141/21, 141/25, 141/26, 141/27, 141/99, 141/100, 141/102, 141/104, 141/105, 141/234, 141/247, 604/407
• US Class Current: 141/234
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like

Abstract

A system and method for automated filling of one or more medical syringes with desired volume(s) and concentration(s) of an injectate solution, such as a contrast solution usable for medical imaging procedures (e.g., x-ray, MRI, ultrasound). The system may incorporate an automated syringe magazine which interfaces with the programmable system controller to deliver the desired number of syringes after the syringes have been filled. Also, the system may utilize a low-pressure pumping arrangement wherein a pumping device engages each receiving syringe and withdraws the plunger of the receiving syringe to pull the desired injectate solution into the receiving syringe by negative pressure.

Claims

1. A system for filling a desired number of receiving syringes with desired volume(s) and desired concentration(s) of an injectate solution, said system comprising:

a syringe filling device comprising;

i) at least one solution container containing a solution at a first concentration;

ii) at least one diluent container containing a diluent which is suitable for diluting said solution;

iii) a mixing apparatus fluidly connected to said solution container and said diluent container, said mixing apparatus being operative to combine a predetermined amount of said solution with a predetermined amount of said diluent to form an injectate solution of a predetermined volume and concentration;

iv) an injectate delivery conduit attached to said mixing apparatus, for delivering said injectate solution of said predetermined volume and concentration;

v) flow directing apparatus fluidly connected to said injectate delivery conduit, and to a plurality of individual syringe filling tubes, said flow directing apparatus being operative to alternately channel the flow of injectate solution received through said delivery conduit, to a single one of said syringe filling tubes;

a syringe-handling magazine adapted to receive and hold a plurality of syringes while each such syringe is connected to a selected one of said syringe filling tubes, said magazine being operative to deliver each syringe after such syringe has been filled with a predetermined volume and concentration of said injectate solution;

pumping apparatus for propelling said solution and said diluent from said solution and diluent containers, through said mixing apparatus, through said injectate delivery conduit, through said flow directing means, and through said syringe delivery tubes and into said syringes; and

,

a programmable controller in communication with said mixing apparatus, said flow directing apparatus, said pumping apparatus and said syringe delivery magazine;

said controller being capable of receiving operator input of the i) desired number of syringes to be filled, ii) the desired volume of injectate solution to be dispensed into each syringe, and iii) the desired concentration of injectate solution to be dispensed into each syringe;

said controller being further operative to send control signals to i) said mixing apparatus, ii) said pumping apparatus, iii) said flow directing apparatus, and iv) said syringe handling magazine, to cause the desired number of syringe(s) to be filled with the desired volume(s) and the desired concentration(s) of injectate solution as input by the operator.

2. The system of claim 1 wherein said pumping apparatus comprises a positive displacement pump positioned between said injectate delivery conduit and said flow directing apparatus such that said pumping apparatus will deliver said injectate solution under positive pressure which is sufficient to advance said injectate solution through said syringe delivery tube and into said syringes.

3. The system of claim 1 wherein said pumping apparatus is a syringe pump which alternately couples to and manipulates each receiving syringe to draw the injectate solution through at least said delivery conduit, and through the syringe delivery tube associated with that syringe, thereby filling each said syringe.

4. The system of claim 1 specifically adapted for use in filling a plurality of syringes with radiographic contrast solution of predetermined volume(s) and concentration(s), and wherein:

said at least one solution container contains a radiographic contrast solution at a first concentration.

5. The system of claim 1 wherein said mixing apparatus comprises an adjustable mixing valve having a first inlet connected to said solution container, a second inlet connected to said diluent container, an outlet connected to said injectate delivery conduit, and at least one adjustable flow regulator for regulating the ratio of solution and diluent which pass into said injectate delivery conduit.

6. The system of claim 1 wherein said flow directing apparatus comprises a manifold having an inlet port connected to said injectate delivery conduit, and a plurality of outlet ports connected to each of said syringe delivery tubes, said manifold further comprising a flow directing element which, in response to signals received from said programmable controller, will alternately channel the flow of injectate solution received through said injectate delivery conduit, to a selected one of said outlet ports and through a selected one of said syringe delivery tubes.

7. The system of claim 1 wherein said syringe-handling magazine comprises a housing having a plurality of syringe holding members formed therein so as to hold said syringes in a substantially linear array, each of said syringe holding members being individually moveable in response to signals received from said controller to thereby dispense each of said syringes after each said syringe has become filled with the predetermined volume an concentration of injectate solution.

8. The system of claim 1 wherein said syringe handling magazine comprises a turntable having a plurality of syringe holding stations formed thereon, each of said syringe holding stations being operative to hold a selected one of said syringes, said turntable being rotatable in response to control signals received from said controller, to deliver each of the syringes held by said syringe holding stations to a location whereat each such syringe may be removed by the operator.

9. The system of claim 8 wherein the flow directing apparatus comprises a stationary injectate delivery hub having an outlet port formed at a first location, and a rotatable annular receiving hub positioned about said delivery hub, said receiving hub having a plurality of receiving ports formed therein, each of said receiving ports of said receiving hub being connected to a receiving syringe positioned in each of said syringe holding stations, said receiving hub being rotatable in conjunction with said turntable to serially move each of the receiving ports of said receiving hub into alignment with the delivery port of said delivery hub such that injectate solution may flow into the receiving syringe connected to that receiving port.

10. A system for filling one or more receiving syringe(s) with desired volume(s) and desired concentration(s) of an injectate solution, said system comprising:

a syringe filling device comprising;

i) at least one solution container containing a solution at a first concentration;

ii) at least one diluent container containing a diluent which is suitable for diluting said solution;

iii) a mixing apparatus fluidly connected to said solution container and said diluent container, said mixing apparatus being operative to combine a predetermined amount of said solution with a predetermined amount of said diluent to form an injectate solution of a predetermined volume and concentration;

iv) an injectate delivery conduit attached to said mixing apparatus, for delivering said injectate solution of said predetermined volume and concentration;

v) a receiving syringe having a barrel and a plunger movably disposed within the barrel, said receiving syringe being connected to said injectate delivery conduit such that when the when the plunger of the syringe is withdrawn in a first direction, injectate will be thereby drawn through the delivery conduit and into the barrel of the receiving syringe;

vi) a syringe pump engageable with said receiving syringe and operative to withdraw the plunger of the receiving syringe to cause the desired volume of injectate solution to be drawn into the barrel of the receiving syringe;

a programmable controller in communication with at least said mixing apparatus, and said syringe pump;

said controller being capable of receiving operator input of i) the desired volume of injectate solution to be dispensed into each receiving syringe, and iii) the desired concentration of injectate solution to be dispensed into each receiving syringe;

said controller being further operative to send control signals to said mixing apparatus and said syringe pump to cause the syringe to be filled with the desired volume and the desired concentration of injectate solution.

11. The system of claim 10 wherein the syringe filling device further comprises:

vii) a flow directing apparatus connected to said injectate delivery conduit, said flow directing apparatus having a plurality of outlets formed therein and means for selectively channeling the flow of injectate from the injectate delivery conduit, out of a selected one of the outlet openings formed in said flow directing apparatus;

viii) a syringe handling magazine adapted to receive a plurality of said receiving syringes with each of said receiving syringes being connected to a selected one of the outlet openings of the flow directing apparatus, said magazine being operative to serially dispense a desired number of the syringes after they have been filled with the desired concentration and the desired volume of injectate;

and wherein said programmable controller is further in communication with said flow directing apparatus and said syringe handling magazine, said controller being further capable of receiving operator input of the desired number of receiving syringes in addition to the desired concentration and volume of injectate to be dispensed into each receiving syringe;

said controller being further operative to send control signals to said flow directing apparatus and said syringe magazine to fill the desired number of syringes with the desired volume and concentration of injectate, and to dispense said desired number of syringes to the operator.

12. The system of claim 11 wherein said flow directing apparatus comprises a manifold having an inlet port connected to said injectate delivery conduit, and a plurality of outlet ports connected to each of said syringe delivery tubes, said manifold further comprising a flow directing element which, in response to signals received from said programmable controller, will alternately channel the flow of injectate solution received through said injectate delivery conduit, to a selected one of said outlet ports and through a selected one of said syringe deliver tubes.

13. The system of claim 11 wherein said syringe-handling magazine comprises a housing having a plurality of syringe holding members formed therein so as to hold said syringes in a substantially linear array, each of said syringe holding members being individually moveable in response to signals received from said controller to thereby dispense each of said syringes after each said syringe has become filled with the predetermined volume an concentration of injectate solution.

14. The system of claim 11 wherein said syringe handling magazine comprises a turntable having a plurality of syringe holding stations formed thereon, each of said syringe holding stations being operative to hold a selected one of said syringes, said turntable being rotatable in response to control signals received from said controller, to deliver each of the syringes held by said syringe holding stations to a location whereat each such syringe may be removed by the operator.

15. The system of claim 14 wherein the flow directing apparatus comprises a stationary injectate delivery hub having an outlet port formed at a first location, and a rotatable annular receiving hub positioned about said delivery hub, said receiving hub having a plurality of receiving ports formed therein, each of said receiving ports of said receiving hub being connected to a receiving syringe positioned in each of said syringe holding stations, said receiving hub being rotatable in conjunction with said turntable to serially move each of the receiving ports of said receiving hub into alignment with the delivery port of said delivery hub such that injectate solution may flow into the receiving syringe connected to that receiving port.

16. The system of claim 10 specifically adapted for use in filling said syringe with radiographic contrast solution of predetermined volume and concentration, and wherein:

said at least one solution container contains a radiographic contrast solution at a first concentration.

17. The system of claim 10 wherein said mixing apparatus comprises an adjustable mixing valve having a first inlet connected to said solution container, a second inlet connected to said diluent container, an outlet connected to said injectate delivery conduit, and at least one adjustable flow regulator for regulating the ratio of solution and diluent which pass into said injectate delivery conduit.

18. A method for filling a desired number of receiving syringes with desired volume(s) and desired concentration(s) of an injectate solution, said method comprising:

a) providing a syringe filling device which comprises;

i) at least one solution container containing a solution at a first concentration;

ii) at least one diluent container containing a diluent which is suitable for diluting said solution;

iii) a mixing apparatus fluidly connected to said solution container and said diluent container, said mixing apparatus being operative to combine a predetermined amount of said solution with a predetermined amount of said diluent to form an injectate solution of a predetermined volume and concentration;

iv) an injectate delivery conduit attached to said mixing apparatus, for delivering said injectate solution of said predetermined volume and concentration;

v) flow directing apparatus fluidly connected to said injectate delivery conduit, and to a plurality of individual syringe filling tubes, said flow directing apparatus being operative to alternately channel the flow of injectate solution received through said delivery conduit, to a single one of said syringe filling tubes;

a syringe-handling magazine adapted to receive and hold a plurality of syringes while each such syringe is connected to a selected one of said syringe filling tubes, said magazine being operative to deliver each syringe after such syringe has been filled with a predetermined volume and concentration of said injectate solution;

pumping apparatus for propelling said solution and said diluent from said solution and diluent containers, through said mixing apparatus, through said injectate delivery conduit, through said flow directing means, and through said syringe delivery tubes and into said syringes; and

,

a programmable controller in communication with said mixing apparatus, said flow directing apparatus, said pumping apparatus and said syringe delivery magazine;

said controller being capable of receiving operator input of the i) desired number of syringes to be filled, ii) the desired volume of injectate solution to be dispensed into each syringe, and iii) the desired concentration of injectate solution to be dispensed into each syringe;

said controller being further operative to send control signals to i) said mixing apparatus, ii) said pumping apparatus, iii) said flow directing apparatus, and iv) said syringe handling magazine, to cause the desired number of syringe(s) to be filled with the desired volume(s) and the desired concentration(s) of injectate solution as input by the operator;

b) programming the controller by inputting the desired number of syringes to be filled, the desired volume of injectate solution to be dispensed into each syringe, and the desired concentration of injectate solution to be dispensed into each syringe;

c) causing control signals to be sent by said controller to said mixing apparatus, said pumping apparatus, said flow directing apparatus and said syringe handling magazine, to thereby fill the desired number of syringe(s) with the desired volume(s) and the desired concentration(s) of injectate solution.

19. The method of claim 18 further comprising the additional step of:

d) causing each receiving syringe to be disconnected from its syringe filling tube after it has been filled with the desired volume and the desired concentration of injectate solution.

20. A method for filling one or more receiving syringes with desired volume(s) and desired concentration(s) of an injectate solution, said method comprising the steps of:

a) providing a syringe filling device which comprises;

i) at least one solution container containing a solution at a first concentration;

ii) at least one diluent container containing a diluent which is suitable for diluting said solution;

iii) a mixing apparatus fluidly connected to said solution container and said diluent container, said mixing apparatus being operative to combine a predetermined amount of said solution with a predetermined amount of said diluent to form an injectate solution of a predetermined volume and concentration;

iv) an injectate delivery conduit attached to said mixing apparatus, for delivering said injectate solution of said predetermined volume and concentration;

v) a receiving syringe having a barrel and a plunger movably disposed within the barrel, said receiving syringe being connected to said injectate delivery conduit such that when the when the plunger of the syringe is withdrawn in a first direction, injectate will be thereby drawn through the delivery conduit and into the barrel of the receiving syringe;

vi) a syringe pump engageable with said receiving syringe and operative to withdraw the plunger of the receiving syringe to cause the desired volume of injectate solution to be drawn into the barrel of the receiving syringe;

a programmable controller in communication with at least said mixing apparatus, and said syringe pump;

said controller being capable of receiving operator input of i) the desired volume of injectate solution to be dispensed into each receiving syringe, and iii) the desired concentration of injectate solution to be dispensed into each receiving syringe;

said controller being further operative to send control signals to said mixing apparatus and said syringe pump to cause the syringe to be filled with the desired volume and the desired concentration of injectate solution;

b) programming the controller by inputting the desired volume of injectate solution to be dispensed into each receiving syringe and the desired concentration of injectate solution to be dispensed into each receiving syringe;

c) causing the controller to send control signals to said mixing apparatus and to said syringe pump to cause each syringe to be filled with the desired volume and the desired concentration of injectate solution.

21. The method of claim 20 further comprising the additional step of:

d) causing each syringe to be disconnected from the device provided in step a, after that syringe has been filled with the desired volume and the desired concentration of injectate solution.

22. The method of claim 20 adapted for filling a desired number of syringes with desired concentration(s) and desired volume(s) of said injectate solution, wherein the syringe filling device provided in step a further comprises:

vii) a flow directing apparatus connected to said injectate delivery conduit, said flow directing apparatus having a plurality of outlets formed therein and means for selectively channeling the flow of injectate from the injectate delivery conduit, out of a selected one of the outlet openings formed in said flow directing apparatus;

viii) a syringe handling magazine adapted to receive a plurality of said receiving syringes with each of said receiving syringes being connected to a selected one of the outlet openings of the flow directing apparatus, said magazine being operative to serially dispense a desired number of the syringes after they have been filled with the desired concentration and the desired volume of injectate;

and wherein said programmable controller is further in communication with said flow directing apparatus and said syringe handling magazine, said controller being further capable of receiving operator input of the desired number of receiving syringes in addition to the desired concentration and volume of injectate to be dispensed into each receiving syringe;

said controller being further operative to send control signals to said flow directing apparatus and said syringe magazine to fill the desired number of syringes with the desired volume and concentration of injectate, and to dispense said desired number of syringes to the operator;

and wherein step b of the method further comprises programming the controller by inputting the desired number of syringes to be filled and the desired volume and concentration of injectate solution to be placed in each such syringe;

and wherein step c of the method further comprises causing the controller to send control signals to said flow directing apparatus and said syringe handling magazine to fill the desired number of syringes with the desired volumes and concentrations of said injectate solution.