Microfabricated therapeutic actuators

• US 5,911,737 A
• Filed: 02/28/1997
• Issued: 06/15/1999
• Est. Priority Date: 02/28/1997
• Status: Expired due to Term

• Current Assignee: Lawrence Livermore National Security LLC (Government of the United States of America)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Northrup, M. Allen, Lee, Abraham P., Krulevitch, Peter A., Benett, William J., Ciarlo, Dino R.
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): TRUONG, KEVIN THAO
• Application Number:
  US08/807,412
• Time in Patent Office: 837 Days
• Field of Search: 128/898, 606/1, 606/205, 606/206, 606/207, 606/211
• US Class Current: 606/209
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/00871 polymeric
• CPC Class Codes: A61B 2017/12068 detachable by heat
• CPC Class Codes: A61B 2017/12077 Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory

Abstract

Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a release actuator for the delivery of embolic coils through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use.

Claims

1. A method for providing controlled deposition of an object, comprising:

providing a quantity of shape memory polymer material;

positioning at least a portion of an object to be deposited into at least a portion of the shape memory polymer material;

heating the material to a temperature above a temperature Tg causing softening of the material;

applying pressure to the heated material causing the material to reshape about the object positioned therein; and

cooling the material to a temperature below Tg causing the material to harden and retain the object therein.

2. The method of claim 1, additionally including positioning the object at a point of use, releasing the object from the material by heating the material to above the temperature Tg, and removing the material.

3. The method of claim 2, wherein heating the material to above the temperature Tg is carried out by one of the group consisting of fluid heating, thermal heating, resistive heating, and optical heating.

4. The method of claim 2, wherein the object to be deposited is a therapeutic material, wherein the positioning of the object is carried out using a catheter, and wherein the heating of the material is carried out using a heated fluid injected through the catheter, thermal heating, resistive heating, or optical heating.

5. A method for retaining and releasing an object from a quantity of shape memory polymer material comprising:

positioning at least a portion of an object to be retained and released into at least a portion of the shape memory polymer material;

heating the shape memory polymer material to a temperature above a temperature Tg causing softening of the material;

applying pressure to the softened material causing the material to reshape about at least a portion of the object positioned therein;

cooling the material to a temperature below the temperature Tg causing the material to harden and retain the object therein; and

reheating the material to a temperature above the temperature Tg causing the material to soften and return to its original configuration thereby enabling the object retained therein to be released therefrom.

6. The method of claim 5, wherein cooling of the material is carried out while pressure is being applied to the material.

7. The method of claim 5, additionally including positioning the retained object at a point of use prior to reheating the material whereby the object is released at the point of use.

8. The method of claim 7, wherein the object comprises a therapeutic material, wherein positioning the object at a point of use is carried out by a catheter, and wherein the heating and reheating of the material is carried out using a heated fluid which can be injected through the catheter, thermal heating, resistive heating, and optical heating.

9. The method of claim 5, wherein heating and reheating of the material is carried out by at least one of the group consisting of fluid heating, thermal heating, resistive heating, and optical heating.