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Delivery system for the localized administration of medicaments to the upper respiratory tract and methods for preparing and using same

  • US 5,912,007 A
  • Filed: 12/06/1996
  • Issued: 06/15/1999
  • Est. Priority Date: 02/29/1996
  • Status: Expired due to Term
First Claim
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1. A medicated composition for the localized administration of a medicament to the upper respiratory tract which comprises:

  • (a) a safe and effective amount of a medicament useful for treating the upper respiratory tract,(b) an ionic polysaccharide,(c) a cross-linking agent to polymerize the ionic polysaccharide wherein said cross-linking agent contains a multivalent ion selected from the group consisting of aluminum, calcium, copper, iron, magnesium, manganlese, zinc, and mixtures thereof,said components (a) (b) and (c) being incorporated into a carrier which is a soft confectionery material or a hard confectionery material, said confectionery material prepared from a high boiling syrup, said material suitable for administration of a medicament to the upper respiratory tract,wherein said medicament is present in an amount from about 0.001% to about 12%, by weight of the delivery system, said ionic polysaccharide is present in an amount from about 0.001% to about 1%, by weight of the composition, and, said cross-linking agent is present in an amount from about 0.001% to about 1.2%, by weight of the composition,such that said polymerization of said ionic polysaccharide takes place in said upper respiratory tract upon the dissolution of said carrier.

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