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Disposable cartridge and method for an assay of a biological sample

  • US 5,912,134 A
  • Filed: 01/14/1997
  • Issued: 06/15/1999
  • Est. Priority Date: 09/02/1994
  • Status: Expired due to Fees
First Claim
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1. A cartridge for dilution of a whole blood sample, the cartridge comprising:

  • a first receptacle configured to receive a whole blood sample;

    a first conduit in fluid communication with said first receptacle configured to move the whole blood sample from said first receptacle;

    a first fluid stop junction in fluid communication with said first conduit, said first fluid stop junction positioned radially outward from said first receptacle, said first fluid stop junction configured to prohibit the whole blood sample from flowing from said first conduit in the absence of centrifugal acceleration applied to the whole blood sample;

    a second receptacle in fluid communication with said first fluid stop junction, said second receptacle configured to receive the whole blood sample, wherein the sample flows from said first receptacle through said first conduit and said first fluid stop junction into said second receptacle upon application of a first low centrifugal acceleration to the whole blood sample in said first conduit, the low centrifugal acceleration having a range of 1 to 100 meters per second per second;

    a third receptacle;

    a second conduit in fluid communication with third receptacle, and configured to move diluent therefrom;

    a second fluid stop junction for connecting said second conduit to said first conduit, said second fluid stop junction configured to move diluent from said second conduit, wherein the diluent flows from said third receptacle through said second conduit and said second fluid stop junction into said first fluid conduit upon application of a second low centrifugal acceleration to the fluid in said second conduit and said second stop junction, the second low centrifugal acceleration having a range of 1 to 100 meters per second per second;

    retaining means for retaining a portion of the whole blood sample and diluent;

    a third stop junction in fluid communication with said second receptacle and in fluid communication with said retaining means.

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